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ProteomicsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutantsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutants
Lymphocyte-specific protein tyrosine kinase (Lck) is crucial for signaling from the T cell receptor (TCR) and is controlled through tyrosine phosphorylations. Phosphorylated Tyr505 (pTyr505) promotes a closed, inactive conformation of Lck, while pTyr394 is critical for kinase activity. Additionally,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-02 | PXD014470 | Pride
T-cells Tyrosine phosphorylation Lck y505f Immunoprecipitation Jurkat-tag cells Lck kinase Lck y192e T cell receptor signalling Lck y192f 
TranscriptomicsTranscriptional profiling of p56lck-deficient regulatory and memory T cells
Signaling through the T cell antigen receptor is essential for the formation of regulatory T (Treg) cells in the thymus and for their involvement in antigen-directed suppression of immune responses. Using a conditional null allele of the gene encoding p56Lck we show here that T cell antigen recepto...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13645 | biostudies-arrayexpress
TranscriptomicsExpression data for Lck-Cre, Med23flox/flox and Med23flox/flox;Lck-Cre thymocytes +/- 3hr exposure to plate bound anti-CD3 antibody
MED23, a subunit of the Mediator coactivator complex, is important for the expression of a subset of MAPK/ERK pathway-dependent target genes; however, the genes in this subset varies between cell types. MAPK/ERK pathway-dependent processes are essential for T-cell development and function, but whet...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57061 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of lck-GFP transgenic zebrafish
The present study was conducted in the frame of the EU-funded Graphene Flagship project. The aim is to evaluate the impact of graphene oxide (GO) on the (innate) immune system using zebrafish as a model. We previously performed single-cell RNA-sequencing of germ-free zebrafish embryos exposed to GO ...
ORGANISM(S): Danio rerio 
2022-07-23 | E-MTAB-11991 | biostudies-arrayexpress
GenomicsCombination therapies to inhibit LCK tyrosine kinase and mTOR signaling in T-cell Acute Lymphoblastic Leukemia
Relapse and refractory T cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis and new combination therapies are sorely needed. This work uncovered potent drug synergies between AKT/mTORC1 inhibitors and the general tyrosine kinase-inhibitor, dasatinib. The combination effectively curbed T-...
EGAS00001005945 | EGA
ProteomicsQuantitative interactomics of Lck-TurboID in living human T cells unveils T cell receptor stimulation-induced proximal Lck interactors
While Lck has been widely recognized to play a pivotal role in the initiation of the T cell receptor (TCR) signaling pathway, an understanding of the precise regulation of Lck in T cells upon TCR activation remains elusive. Investigation of protein-protein interaction (PPI) using proximity labeling ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-12 | PXD020759 | Pride
Proximity labeling T cell receptor Lck Turboid Interactome 
UnknownPredictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation.
Not available
S-EPMC4978775 | biostudies-literature
TranscriptomicsFL5.12 Bfl-1DC/p53DD-derived splenic tumors compared to the parental FL5.12 Bfl-1DC/p53DD cell line
The antiapoptotic Bcl-2 family member Bfl-1 is upregulated in many human tumors in which NF-kB is implicated, and contributes significantly to tumor cell survival and chemoresistance. We previously found that NF-kB induces transcription of bfl-1, and that the Bfl-1 protein is also regulated by the u...
ORGANISM(S): Mus musculus 
2010-03-23 | E-GEOD-18204 | biostudies-arrayexpress
TranscriptomicsExpression data from thymic lymphomas of Lck-MyrAkt positive mice with WT or KD mTOR expression
Lck-MyrAkt2 mice develop spontaneous thymic lymphomas at approximately 100-200 days of age, driven in part by a consitutatively-active AKT (due to myristoylation). mTOR Knock Down mice were crossed with Lck-MyrAkt postive mice to model the affects of decreasing mTOR activity on tumors with an activa...
ORGANISM(S): Mus musculus 
2015-09-15 | E-MTAB-3242 | biostudies-arrayexpress
UnknownLck bound to coreceptor is less active than free Lck.
Not available
S-EPMC7355011 | biostudies-literature
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