Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
This a model from the article:
Prediction of photoperiodic regulators from quantitative gene circuit models.
Salazar JD, Saithong T, Brown PE, Foreman J, Locke JC, Halliday KJ, Carré IA, Rand DA, Millar AJ Cell
2009 Dec; 139(6): 1170-9 20005809
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This model is from the article:
Multiple light inputs to a simple clock circuit allow complex biological rhythms
Troein C, Corellou F, Dixon LE, van Ooijen G, O'Neill JS, Bouget FY, Millar AJ.
Plant J.2011 Apr;66(2):375-85.
21219507,
Abstract:
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Data from ProteomeXchange, PXD ID: PXD000975. File: F010311.mgf. Published as part of Proteomics. 2015 Apr 29 . From the Abstract: {{i}} Casein kinase 2 (CK2) is a protein kinase that phosphorylates a plethora of cellular target proteins involved in processes including DNA repair, cell cycle contro...
Proteomics and phosphoproteomics analyses of circadian time course samples of Arabidopsis thaliana rosettes (22 DAS) in constant light.
Two independent experiments, with global proteomics and phosphoproteomics analyses for each.
Experiment I has a time point every 4h from ZT12 to ZT32, experiment 2 ...
Interaction proteomics time course over 24h every 4h, looking for novel interactors of the circadian clock and flowering time protein GIGANTEA. Plants expressing 35S:GIGANTEA:3xFlag6His were used, as well as WT plants for a background control.
Mass spectrometry-based proteomics was carried out on Naso- and oropharyngeal swabs collected from infants and children presenting to hospital with both mild and severe respiratory illnesses as well as age-matched control children who were well and sampled from home.
Systems biological approaches to study the Arabidopsis thaliana circadian clock have mainly focused on transcriptomics while little is known about the proteome, and even less about post-translational modifications. Evidence has emerged that post-translational protein modifications, in particular pho...
