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UnknownImpact and effectiveness of Rotavin-M1 under conditions of routine use in two provinces in Vietnam, 2016-2021, an observational and case-control study.

Background

Half of diarrhea hospitalizations in children aged <5 years in Vietnam are due to rotavirus. Following introduction of a locally developed and licensed oral rotavirus vaccine, Rotavin-M1, into the routine immunization program in two Vietnamese provinces, Nam Dinh and TT Hue, we de...
S-EPMC10485664 | biostudies-literature
UnknownDevelopment of optimized protocol for culturing African swine fever virus field isolates in MA104 cells.
The goal of this study was to identify a candidate commercial cell line for the replication of African swine fever virus (ASFV) by comparing several available cell lines with various medium factors. In the sensitivity test of cells, MA104 and MARC-145 had strong potential for ASFV replication. Next,...
S-EPMC9536354 | biostudies-literature
UnknownA highly sensitive electrochemical sensor for the detection of lead(ii) ions utilizing rice-shaped bimetallic MOFs incorporated reduced graphene oxide.
The detection of lead ions (Pb2+) in water is of critical importance due to the harmful effects of lead on human health and the environment. Traditional detection methods often require high user expertise, expensive equipment, and complex analytical procedures. Electrochemical sensors hav...
S-EPMC11833290 | biostudies-literature
UnknownIonic liquid-immobilized silica gel as a new sorbent for solid-phase extraction of heavy metal ions in water samples.
In the current study, we have developed a solid-phase extraction (SPE) method with novel C18-alkylimidazolium ionic liquid immobilized silica (SiO2-(CH2)3-Im-C18) for the preconcentration of trace heavy metals from aqueous samples as a prior step to their ...
S-EPMC9260518 | biostudies-literature
UnknownLotusin A: a novel pyrrole terpenoid hydrid from lotus roots (<i>Nelumbo nucifera</i> Gaertn.).
Nelumbo nucifera Gaertn. has been used as a traditional medicine and food. To date, many unknown constituents have been discovered. Most of the researches on secondary metabolites and their pharmacological properties focus on alkaloid derivatives. In this study, a novel pyrrole terpenoid hydr...
S-EPMC12705226 | biostudies-literature
UnknownZIKV Inhibitors Based on Pyrazolo[3,4-d]pyridazine-7-one Core: Rational Design, In Vitro Evaluation, and Theoretical Studies.
The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations to date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-d]pyridazine-7-one scaffold, we synthesized 16 derivatives and screened their ability to interfe...
S-EPMC10753549 | biostudies-literature
UnknownAntibacterial efficacy of low-dosage silver nanoparticle-sodium alginate-chitosan nanocomposite films against pure and clinical acne strains.
The silver nanoparticles-sodium alginate-chitosan (AgNPs-Alg-Chi) nanocomposite film is a compelling material with demonstrated antibacterial efficacy against various pure bacterial strains. However, its potential cytotoxicity at elevated Ag doses warrants investigation. There is a notable dearth of...
S-EPMC11492429 | biostudies-literature
UnknownInvestigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil.
Eighteen active substances, including 17 organosulfur compounds found in garlic essential oil (T), were identified by GC-MS analysis. For the first time, using the molecular docking technique, we report the inhibitory effect of the considered compounds on the host receptor angiotensin-converting enz...
S-EPMC7123907 | biostudies-literature
UnknownEffect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial.

Objective

To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza.

Design

Double blind randomised trial.

Setting

Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam.<...
S-EPMC3668094 | biostudies-literature
UnknownAwareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

Background

Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave.

Methods

This multinational, multicenter...
S-EPMC8694437 | biostudies-literature
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