136799 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
MetabolomicsDiscovery of isokurarinone as an ATCase-Engaging Lead with potent activity against methicillin-resistant Staphylococcus aureus

The global proliferation of methicillin-resistant Staphylococcus aureus (MRSA) persists as a significant contributor to challenging infections, highlighting the urgent necessity for therapies that utilize novel mechanisms. Aspartate transcarbamoylase (ATCase), which catalyzes the initial committe...

2026-01-14 | MTBLS13673 | MetaboLights
MetabolomicsComprehensive Evaluation of Anti-hyperuricemic Effect of Red Kidney Bean Anthocyanins and Molecular Screening of the Lead Candidate

Hyperuricemia (HUA) has emerged as an increasingly prevalent metabolic disorder worldwide. This study aimed to investigate the effects of red kidney bean (Phaseolus vulgaris L.) anthocyanins (RKBA) on alleviating HUA and screen the lead candidate. RKBA effectively inhibited XOD in vitro. In vivo ...

2025-10-29 | MTBLS13234 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila Roo lines grown on lead containing food to investigate lead toxicity
75 Diosophilia Roo lines, recominant inbred lines, were raised to adulthood either on conventional diet or diet supplemented with lead acetate. Whole flies were used for RNA extraction. RNA was run on Dros Genome 2 arrays. Each line also genotyped for 88 markers; Control food consisted of standard c...
ORGANISM(S): Drosophila melanogaster 
2009-06-08 | E-GEOD-11695 | biostudies-arrayexpress
TranscriptomicsMethodoligies for identifying lead toxicity
Quantifying impact of lead on cytokine production and gene expression in PBMCs Cells were treated with 10mkM lead acetate for one day, washed and grown in RPMI for the second day. Lead acetate was not added to matching control cells.
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-37567 | biostudies-arrayexpress
TranscriptomicsEffects of Developmental Lead Exposure on the Hippocampal Transcriptome.
In this study we analyzed the effects of lead-exposure up hippocampal gene expression in males and females exposed to 0ppm, 250ppm and 750ppm lead during two different developmental periods, perinatal (in utero through to weaning at PND21) and postnatal (PND0-PND45). All tissue was taken at PND 55....
ORGANISM(S): Rattus norvegicus 
2012-05-30 | E-GEOD-38348 | biostudies-arrayexpress
ProteomicsImpact of intermittent lead exposure on hominid brain evolution
Lead Exposure and Human Brain Evolution: A 2-Million-Year Perspective This study reveals that lead exposure was pervasive throughout human evolution, not just a modern phenomenon. Researchers analyzed 51 fossil teeth from multiple hominid species spanning 2+ million years across three continents, fi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD067623 | Pride
Lead exposure  hominid brain evolution  nova1–foxp2 axis 
TranscriptomicsGenetic Diversity Influences the Response of the Brain to Developmental Lead Exposure.
In this study we analyzed the effects of lead-exposure up hippocampal gene expression in males and females exposed to 0ppm, 250ppm and 750ppm lead during two different developmental periods, perinatal (in utero through to weaning at PND21) and postnatal (PND0-PND45), across three strains (Fischer, L...
ORGANISM(S): Rattus norvegicus 
2014-04-10 | E-GEOD-56666 | biostudies-arrayexpress
ProteomicsLead eliminating activity of Auricularia polytricha glycoprotein protects against lead acetate-induced hepatorenal toxicity in rats via positive immunoregulation pathway
Lead is a ubiquitous environmental and industrial pollutant. Its nonbiodegradable toxicity induces a plethora of human diseases. The current study was undertaken to purify a novel 252-kDa bioactive glycoprotein containing 1.15% carbohydrate from the edible fungus Auricularia polytricha with the abil...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-04 | PXD040493 | Pride
Rat Lead Liver 
TranscriptomicsLead Modulates trans- and cis-eQTLs in Drosophila melanogaster Heads
The goal was to study the effects of lead exposure on gene expression and identify the lead-responsive genes. After detecting 1,536 cis-eQTLs (FDR ≤ 10%) and 952 trans-eQTLs, we focused our analysis on Pb-sensitive “trans-eQTL hotspots”. 158 randomly selected Drosophila Synthetic Population Re...
ORGANISM(S): Drosophila melanogaster 
2016-06-10 | E-GEOD-83141 | biostudies-arrayexpress
TranscriptomicsInfluence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)
Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of a...
ORGANISM(S): Pimephales promelas 
2008-04-06 | E-GEOD-8404 | biostudies-arrayexpress
Sort   by:  
 Page size