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TranscriptomicsIntegrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
We have found that thyroid hormones (THs), acting as soluble integrin αvβ3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated αvβ3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. CUTLL1 cel...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-63122 | biostudies-arrayexpress
UnknownTherapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.
Not available
S-EPMC9310269 | biostudies-literature
UnknownPopulation-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing.
Not available
S-EPMC7501153 | biostudies-literature
UnknownPKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain.
Not available
S-EPMC5292662 | biostudies-literature
TranscriptomicsTranscription profiling of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis in highly enriched cell populations
We report a comprehensive large-scale expression profiling analysis of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis using High Density Oligonucleotide Microarrays and highly enriched cell populations. Among 11955 rat loci investigated, 1268 were identified as differ...
ORGANISM(S): Rattus norvegicus 
2004-03-01 | E-MEXP-31 | biostudies-arrayexpress
ProteomicsPentose phosphate pathway is essential for the resistance of Gluconacetobacter diazotrophicus PAL5 to zinc
Zinc (Zn) is an essential metal for the metabolism of bacteria, but in high concentrations, it may be toxic to cells. Gluconacetobacter diazotrophicus is a Gram-negative bacterium characterized by promotes plant growth. Moreover, G. diazotrophicus can survive under challenging conditions, including ...
ORGANISM(S): Gluconacetobacter diazotrophicus PA1 5 
2026-09-11 | PXD065016 | Pride
Plant growth-promoting bacteria Pgl Mutagenesis Proteome Toxic metal 
UnknownLoss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.
Not available
S-EPMC5537137 | biostudies-literature
UnknownIdentification of Highly Variable Supernumerary Chromosome Segments in an Asexual Pathogen.
Not available
S-EPMC4920403 | biostudies-literature
TranscriptomicsCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma
Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls post-transcriptional dynamics of key mRNA species including those encoding BCL6, MYC and BCL2. Using a proteomics approach, we found that Hsp90 binds to and maintains acti...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-63265 | biostudies-arrayexpress
UnknownUncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells.
Not available
S-EPMC12535409 | biostudies-literature
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