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ProteomicsChemoproteomic target deconvolution of Lipoic acid reveals Histone Deacetylases as the main targets
Here we set out to identify protein targets of Lipoic acid and Lipoamide by chemical proteomics approaches. We generated Lipoamide-based affinity matrices to pulldown target proteins and quantify them via bottom-up proteomics. Use of the same affinity matrix in dose dependent compeition assays allow...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD036810 | Pride
Lc-msms Drug target deconvolution Cancer cell lines 
ProteomicsAza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation
We report the first selective chemical probes for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique among the 11 zinc-dependent HDAC hydrolases. Taking inspiration from HD...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD032671 | Pride
Histone deacetylase Polyamines Be(2)-c Drug discovery Chemical proteomics Chemical biology Chemical probes Lc-ms/ms 
ProteomicsTarget deconvolution of HDAC pharmacopoeia highlights MBLAC2 as common off-target
HDAC drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a chemical proteomics assay using three promiscuous chemotypes and quantitative mass spectrometry that we deployed to establish the target landscape of 56 HDAC...
ORGANISM(S): Homo sapiens (Human) 
2022-05-11 | PXD026657 | Pride
Human Lc-msms Cancer cell lines Affinity pulldown Dda 
ProteomicsChemoproteomic selectivity profiling of TAK285 in NALM6 cells
We used dose-dependent chemoproteomic competition assays to profile the proteome-wide target binding and selectivity of the kinase inhibitor TAK285.
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD064676 | Pride
Lc-ms/ms 
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