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ProteomicsApoA-I [human] (CSL112) infusion increases LCAT levels in HDL particles and promotes reverse cholesterol transport
Background: High-density lipoprotein (HDL)-cholesterol is inversely correlated with cardiovascular risk, but increasing its circulating concentration is insufficient to prevent adverse cardiovascular outcomes. Instead, the emerging paradigm is on increasing the function of HDL and its major protein...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057196 | Pride
Lecithin-cholesterol acyl transferase Proteome Csl112 High-density lipoprotein Acute myocardial infarction 
UnknownEffects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.
Not available
S-EPMC12462640 | biostudies-literature
UnknownEffect of recombinant human lecithin cholesterol acyltransferase infusion on lipoprotein metabolism in mice.
Not available
S-EPMC2957790 | biostudies-literature
ProteomicsDyslipidemia Alters HDL Metabolism and Function in NAFLD
Dyslipidemia and inflammation play key roles in the pathogenesis of both nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. NAFLD, particularly its severe form nonalcoholic steatohepatitis (NASH) is associated with increased cardiovascular disease (CVD) risk. HDL (high density lipoprotein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-12 | PXD010199 | Pride
Ss Nonalcoholic Metabolism Nafld Steatosis Dyslipidemia Hepatic Simple Nash Inflammation Disease Cardiovascular Steatohepatitis 
UnknownDiagnosis and treatment of high density lipoprotein deficiency.
Not available
S-EPMC5331615 | biostudies-literature
UnknownrHDL modeling and the anchoring mechanism of LCAT activation.
Not available
S-EPMC7859856 | biostudies-literature
UnknownMeasures of high-density lipoprotein function in men and women with severe aortic stenosis.
Not available
S-EPMC9148512 | biostudies-literature
UnknownGenetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
Not available
S-EPMC1852704 | biostudies-literature
UnknownMetabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
Not available
S-EPMC7934878 | biostudies-literature
UnknownSubstitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women.
Not available
S-EPMC2905850 | biostudies-literature
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