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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownFollicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation.
Not available
S-EPMC3709054 | biostudies-literature
UnknownRegorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial.
Not available
S-EPMC5019744 | biostudies-literature
UnknownSelective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.
Not available
S-EPMC6905485 | biostudies-literature
ProteomicsInteractome screening of C9orf72 dipeptide repeats reveals sequestration and functional impairment of VCP by polyGA
Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation to produce unnatural dipeptide rep...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD024120 | Pride
Proximity labeeling Proteomics Amyotrophic lateral sclerosis Als Valosin-containing protein Vcp Bioid Neurodegeneration Dipeptide repeats 
UnknownTransformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms.
Not available
S-EPMC2532951 | biostudies-literature
UnknownIncidence of Respiratory Syncytial Virus-Associated Hospitalization Among Adults in Ontario, Canada, 2017-2019.
Not available
S-EPMC12614998 | biostudies-literature
GenomicsBC Cancer, part of the Provincial Health Services Authority, Technology Development Office, Data Access Committee (PHSA TDO DAC)
Access to data generated by BCCA is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000011 | EGA
UnknownDevelopment of a High-Risk Medication List for Australian Residential Aged Care: A Modified Delphi Study.
Not available
S-EPMC12945874 | biostudies-literature
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