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TranscriptomicsPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis
In a manner similar to ubiquitin, the prokaryotic ubiquitin-like protein (Pup) has been shown to target proteins for degradation via the proteasome in mycobacteria. However, not all actinobacteria possessing the Pup protein also harbor a proteasome, suggesting fates for pupylated proteins other than...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-06-24 | E-GEOD-48038 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 2 outbreak strains of E. coli O157:H7 following exposure to epithelial cells
Two outbreak strains of E. coli O157:H7 differ phylogenetically, in gene content, and in epidemiological characteristics. The working hypothesis in this experiment was that these strains will also differ in the transcription of shared virulence genes. Indeed, following a 30 minute exposure to epithe...
ORGANISM(S): Escherichia coli 
2010-05-05 | E-GEOD-17389 | biostudies-arrayexpress
TranscriptomicsContext-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in susceptibility to autoimmune conditions. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner. The aim this experiment was i) to characterise changes in gene expression with LPS, and ii) post-...
ORGANISM(S): Homo sapiens 
2019-08-17 | E-MTAB-8225 | biostudies-arrayexpress
TranscriptomicsContext-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner. Here we show monocyte surface and soluble IL7R (sIL7R) protein are markedly expressed in response to lipopolysacc...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-8207 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of intestinal crypts of Red2Kras and Red2Pi3k mice
We isolated mutant and wild-type epithelial cells as well as mesenchymal and immune cells from Confetti, R2Kras and R2Pi3k lines at 2 weeks post-induction and generated single-cell RNA-seq data from them.
ORGANISM(S): Mus musculus 
2021-04-04 | E-MTAB-8656 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation genome wide location analysis of yeast transcriptional regulators under multiple growth conditions
Genomic binding of 203 transcriptional regulatory proteins under various conditions. Hybridizations of fluorescently-labelled immunoprecipitated vs. whole-cell extract samples on S. cerevisiae intergenic arrays.
ORGANISM(S): Saccharomyces cerevisiae 
2004-09-02 | E-WMIT-10 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow hematopoietic stem cells and myeloid progenitors from mice with conditional deletion of Forkhead O (FoxO) family of transcription factors
To investigate the role of FoxO transcription factors as mediators of hematopoietic stem cell resistance to oxidative stress. Experiment Overall Design: Study the effect of the deficiency of FoxO1, FoxO3, and FoxO4 in murine bone marrow hematopoietic stem cells and myeloid progenitors on expression ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6623 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31948 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of Tal1 knockout chimeric mouse embryos at embryonic day 8.5 of mouse development
Chimeric embryos were generated to investigate the effect of Tal1 knockout in mouse embryos by single-cell RNA-sequencing. Tal1 is an essential transcription factor for the formation of the embryonic blood. Embryo chimerism permits the analysis of the effects of Tal1 knockout without the confounding...
ORGANISM(S): Mus musculus 
2018-12-05 | E-MTAB-7325 | biostudies-arrayexpress
TranscriptomicsRNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from frog
This experiment contains the Xenopus tropicalis subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog, ...
ORGANISM(S): Xenopus tropicalis 
2012-12-22 | E-MTAB-3726 | biostudies-arrayexpress
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