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MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
TranscriptomicsDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Dendritic cells (DCs) are crucial for sensing pathogens and triggering immune response. GM-CSF myeloid dendritic cells (GM-DCs) secrete several cytokines including IL-2 upon activation by pathogen associated molecular pattern (PAMP) ligands. DC IL-2 has been shown to be important for innate and adap...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-58120 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD8 T-cells predicts disease course in Crohn's disease and ulcerative colitis
The natural history of Crohn's disease (CD) and ulcerative colitis (UC) is variable. In patients with frequently-relapsing/steroid-refractory disease, sustained remission is more likely if immunomodulators are introduced earlier. However, many patients experience quiescent disease without immunomodu...
ORGANISM(S): Homo sapiens 
2011-07-19 | E-MTAB-331 | biostudies-arrayexpress
UnknownExploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer's disease.
Not available
S-EPMC11571668 | biostudies-literature
TranscriptomicsGenotyping of human glioma - assessing the significance of chromosomal aberrations in cancer
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics and targeted therapeutics. Systematic efforts to analyze cancer genomes are underway, but the analysis is hampered by the lack of a statistical framework to distinguish mean...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9635 | biostudies-arrayexpress
TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
TranscriptomicsRecurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 27K DNA Methylation]
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 s...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-30653 | biostudies-arrayexpress
TranscriptomicsRecurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 450K DNA Methylation]
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 s...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-31848 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the genetic regulation of gene expression in human neutrophils
Here we report an expression dataset of isolated neutrophils from 114 healthy individuals of Chinese ethnicity collected in Singapore. A total of 114 individuals with no case control stratification.
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-70044 | biostudies-arrayexpress
GenomicsItalian Primary Biliary Cirrhosis Study

A Genome-wide association study of primary biliary cirrhosis (PBC) with an Italian cohort and loci meeting suggestive criteria were confirmed using a replication dataset from a previous Canadian study. The results confirmed associations for IL12A, IL12RB2, and HLA (peak between DQA1 and DQB1) and...

phs000444.v1.p1 | EGA
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