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TranscriptomicsHT-SELEX of recombinant C2H2 zinc finger domains of Sall4
To define the sequence preference of SALL4 C2H2 zinc finger domains, we performed SELEX coupled with high-throughput sequencing (HT-SELEX) using the purified SALL4 ZFC1, ZFC2 and ZFC4 domains combined with no protein control experiment.
ORGANISM(S): artificial sequences 
2021-01-05 | E-MTAB-9236 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mouse embryonic stem cells after knockout and re-introduction of Sall4a
Sall4 is a stem cell factor which is important for embryogenesis. In order to address transcriptional changes, we re-introduce Sall4 in homozygous Sall4 knockout (KO) mouse embryonic stem cells through random integration of Sall4 cDNA using a Piggybac vector which is Dox inducible. We also re-introd...
ORGANISM(S): Mus musculus 
2021-01-05 | E-MTAB-9202 | biostudies-arrayexpress
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
UnknownSelected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.
Not available
S-EPMC6254048 | biostudies-literature
TranscriptomicsToc1, Toc2, and Skn7 null mutants treated with Flucytosine
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30154 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of eukaryotic genes affected by Gromwell extract
BACKGROUND: Lithospermum erythrorhizon, popularly known as Gromwell, is a perennial herb belonging to the family of Boraginaceae and its extract is known to have diverse pharmacological, cosmetic, and nutritional values for human. Nevertheless the biological influence of Gromwell extract on general ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-01-10 | E-GEOD-43370 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Escherichia coli O157:H7 EDL933 during heat shock using microarrays
The transcriptome of Escherichia coli K-12 has been widely studied over a variety of conditions for the past decade while such studies involving E. coli O157:H7, its pathogenic cousin, are just now being conducted. To better understand the impact of heat shock on E. coli O157:H7, global transcript l...
ORGANISM(S): Escherichia coli 
2009-04-01 | E-GEOD-11463 | biostudies-arrayexpress
UnknownStructural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Not available
S-EPMC3890372 | biostudies-literature
TranscriptomicsTranscription profiling of human lung cancer patients with sqamous cell or adenocarcinoma at different stages of disease to identify gene signatures to predict prognosis
Gene signatures were derived to separate high risk patients from low risk ones. Experiment Overall Design: 130 samples from 129 patients
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-4573 | biostudies-arrayexpress
TranscriptomicsDelta-mbs1 mutant
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30156 | biostudies-arrayexpress
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