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ProteomicsA Derivatization-Free PRM Workflow for Quantitative, Site-Specific Analysis of Histone Post-Translational Modifications
Histone post-translational modifications (PTMs) are key regulators of chromatin architecture and gene expression. Although DIA-based platforms for histone PTM quantification are available, multiplexed targeted assays remain underdeveloped. In addition, bottom-up workflows frequently rely on chemical...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-09-09 | PXD071393 | Pride
Ptms Prm Skyline Quantitation Histone Argc 
ProteomicsThe Prostacyclin Receptor is a NRF2-regulated Immune Checkpoint in CD8 T cells
Immune checkpoint inhibitor (ICI) therapies revitalize anti-cancer responses by intercepting protein-protein interactions between exhausted CD8 T (Tex) cells and cancer cells (e.g. PD-1:PD-L1). However, up to 50% of patients receiving ICIs relapse, warranting further interrogation of the underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD052688 | Pride
Adoptive cell therapy T cell exhaustion Immune checkpoint 
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