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ProteomicsOpen-Gate Mutants of the Mammalian Proteasome Show Enhanced Ubiquitin-Conjugate Degradation
When in the closed form, the axial substrate translocation channel of the proteasome core particle (CP) is topologically blocked by the convergent N-termini of subunits. To probe the role of channel gating in mammalian proteasomes, we have deleted the N-terminal tail of 3. The resulting 3N proteaso...
ORGANISM(S): Homo sapiens (Human) 
2016-03-01 | PXD003577 | Pride
Proteasome Proteomics Gate Tau Oxidative stress Aggregation 
MetabolomicsThe Green Tea Modulates Large Intestinal Microbiome and Exo/Endogenous Metabolome altered through Chronic UVB-exposure (Endogenous assays)
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbi...
2018-09-14 | MTBLS527 | MetaboLights
TranscriptomicsThe responses of astrocytes stimulated by extracellular a-synuclein
Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...
ORGANISM(S): Rattus norvegicus 
2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress
TranscriptomicsThe Path to Triacylglyceride Obesity in the sta6 Strain of Chlamydomonas reinhardtii
When the sta6 (starch-null) strain of the green microalga Chlamydomonas reinhardtii is nitrogen-starved in acetate and then "boosted" after two days with additional acetate, the cells become "obese" after eight days, with triacylglyceride-filled lipid bodies filling their cytopla...
ORGANISM(S): Chlamydomonas reinhardtii 
2014-03-09 | E-GEOD-55253 | biostudies-arrayexpress
ProteomicsHuman synovial fluid proteomics reveals potential early-diagnostic biomarkers for ankylosing spondylitis
[Background] Ankylosing spondylitis (AS), affecting 0.5% of the population, is a chronic inflammatory rheumatic disease affecting the axial skeleton and peripheral joints. The etiology of this disease is still poorly understood, but it may be involved with the interaction of genetic and environmen...
ORGANISM(S): Homo sapiens (Human) 
2021-07-15 | PXD016620 | Pride
Synovial fluid Proteomics Biomarker Ankylosing spondylitis 
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
TranscriptomicsMPSS profiling of embryonic gonad and primordial germ cells
We used the MPSS technology to uncover gene expression profiling in a greater depth in the early embryonic gonads and primordial germ cells (PGCs) in the chicken. Total numbers of sequenced signatures were 1,012,533 and 995,676 for the PGCs and gonad. Using a false discovery rate cut-off of 0.05, we...
ORGANISM(S): Gallus gallus 
2007-02-28 | E-GEOD-5909 | biostudies-arrayexpress
UnknownAssociation of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.
Not available
S-EPMC11399067 | biostudies-literature
UnknownConsiderations and consequences of allowing DNA sequence data as types of fungal taxa.
Not available
S-EPMC6048565 | biostudies-literature
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
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