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UnknownClinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.

Background

Although adolescent and young adult (AYA) cancers are characterized by biological features and clinical outcomes distinct from those of other age groups, the molecular profile of AYA cancers has not been well defined. In this study, we analyzed cancer genomes from rare types of me...
S-EPMC4772349 | biostudies-literature
UnknownCoronavirus Disease Exposure and Spread from Nightclubs, South Korea.
At least 246 cases of coronavirus disease (COVID-19) have been linked to nightclubs in Seoul, South Korea. During the April 30-May 5 holiday, young adults from across the country who visited nightclubs in Seoul contracted COVID-19 and spread it nationally. Nightclubs were temporarily closed to limit...
S-EPMC7510694 | biostudies-literature
UnknownWeekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma.

Aim

To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC).

Methods

A multi-center, open-label, prospective phase II study was designed. Thirty-three esophageal SCC patients with document...
S-EPMC4394089 | biostudies-literature
UnknownA case of early diagnosis of pulmonary capillary hemangiomatosis in a worker with exposure to silica.

Background

Pulmonary capillary hemangiomatosis (PCH) is a progressive and refractory vascular disease in the lung. Pulmonary hypertension is frequently combined with PCH when capillary proliferation invades to nearby pulmonary vascular systems. It is difficult to differentiate PCH from other...
S-EPMC6651969 | biostudies-literature
UnknownGenome-Wide Analysis of Human Metapneumovirus Evolution.
Human metapneumovirus (HMPV) has been described as an important etiologic agent of upper and lower respiratory tract infections, especially in young children and the elderly. Most of school-aged children might be introduced to HMPVs, and exacerbation with other viral or bacterial super-infection is ...
S-EPMC4821609 | biostudies-literature
UnknownPulmonary Tuberculosis and Risk of Lung Cancer: A Systematic Review and Meta-Analysis.
Pulmonary tuberculosis (TB) is a known risk factor for lung cancer. However, a detailed analysis of lung cancer type, age, sex, smoking, and TB burden associated with geographic and socioeconomic status has not been performed previously. We systematically appraised relevant observational studies rep...
S-EPMC8836400 | biostudies-literature
UnknownThe Kynurenine Pathway and Mediating Role of Stress in Addictive Disorders: A Focus on Alcohol Use Disorder and Internet Gaming Disorder.
Stress plays an important role in the pathophysiology of addictive disorders. The kynurenine (KYN) pathway involved in neuroimmune and cognitive functions is activated under stress. However, the neuroimmunological-neurocognitive mechanisms in the role of stress in addictive disorders are unclear sti...
S-EPMC9037037 | biostudies-literature
UnknownKorean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics.

Objective

The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer's disease (AD) and to investigate how multi-faceted lifetime experiences and bodi...
S-EPMC5714729 | biostudies-literature
ProteomicsnextPP for chromosome-based proteomic research using neXtProt and GENCODE databases
In this study, we introduce a streamlined pipeline using customized and concatenated GENCODE and neXtProt databases with controlled false discovery rate (FDR) for finding GENCODE ASVs and missing proteins while mapping onto single amino acid variants (SAAVs) from Hippocampal dataset.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-25 | MSV000081385 | MassIVE
UnknownImpact of maternal age on neonatal outcomes among very preterm infants admitted to Chinese neonatal intensive care units: a multi-center cohort study.

Background

The percentage of advanced maternal age (aged over 35 years) mothers has been rising across the world, the evidence of maternal age on neonatal outcomes from low- and middle-income countries is scarce. Our objective was to evaluate the effect of maternal age on mortality and major...
S-EPMC9360824 | biostudies-literature
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