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ProteomicsSpatial Multi-Omics Reveals Region-Specific Molecular Signatures in a 6-OHDA Model of Parkinson’s Disease
Parkinson’s disease (PD) is characterized by complex molecular and circuit-level alterations that extend beyond dopaminergic neurodegeneration, yet the spatial integration of metabolic and proteomic changes remains insufficiently explored. Here, we combined time-of-flight secondary ion mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD071834 | Pride
ProteomicsIntegrated tissue and serum proteomics on magnet-guided photothermal therapy using Au/Fe/Au trilayer nanodiscs
Nanodiscs are emerging as promising nanomaterials for localized therapies as they enable magnetic targeting and near-infrared (NIR) laser–driven photothermal stimulation. In this study, we performed comprehensive proteomic analyses of both tissue and serum from mouse models to elucidate the effects ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-15 | PXD068909 | Pride
Photothermal therapy Serum Proteomics Tissue Nanodisc 
ProteomicsGlobal proteomics to study silica nanoparticle-induced cytotoxicity and its mechanisms in HepG2 cells
Silica nanoparticles (SiO2 NPs) are commonly used in medical and pharmaceutical fields. Research into the cytotoxicity and overall proteomic changes occurring during initial exposure to SiO2 NPs is limited. We investigated the mechanism of toxicity in human liver cells according to exposure time [0,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024206 | Pride
Silica nanoparticles  cytotoxicity  label-free quantification  proteomic analysis  mass spectrometry 
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