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ProteomicsProteomic Analysis of Extracellular Vesicles Derived from Human Pluripotent Stem Cells
Extracellular vesicles (EVs) and secretory factors are key to intercellular communication, yet their molecular dynamics in human pluripotent stem cells (hPSCs) are not well understood. We identified a key EV surface protein that regulates hPSC stemness, enhances growth, and promotes EV endocytosis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056373 | Pride
Extracellular vesicles Human pluripotent stem cells 
UnknownActive photonic wireless power transfer into live tissues.
Not available
S-EPMC7382277 | biostudies-literature
ProteomicsCTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
The pleiotropic CCCTC-binding factor (CTCF) plays a role in homologous recombination (HR) repair of DNA double-strand breaks (DSBs). However, the precise mechanistic role of CTCF in HR remains largely unclear. Here, we show that CTCF engages in DNA end resection, which is the initial, crucial step i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014441 | Pride
Pleiotropic ccctc-binding factor Mre11 Human Interactome 
GenomicsAKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.
Purpose: In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 of core histone H3 (H3-T45) Result: By genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis, H3-T45 phosphorylation was distributed throughout DNA damage-responsive gene loci, particularly i...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-67699 | biostudies-arrayexpress
Genomicsena-DATASET-asan-ccgd-27-09-2019-00:22:21:191-59 - samples
231 HCC exome sequencing with Sureselect 50Mb
EGAD00001005361 | EGA
GenomicsThese are from Korean HCC samples with exome sequencing
Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identif...
EGAS00001000604 | EGA
Genomicswhole exome sequencing of Korean hepatocellular carcinomas
Data Access Committee EGAC00001000329
EGAC00001000329 | EGA
UnknownThe Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.
Not available
S-EPMC12675286 | biostudies-literature
UnknownMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Not available
S-EPMC4737645 | biostudies-literature
UnknownMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.
Not available
S-EPMC10762575 | biostudies-literature
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