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Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet (HFD)-induced obesity, and overexpressed Sestrins activate AKT ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD015824 | Pride
Wild type and Batf deficient T cells were stimulated under various combinations of IL-6 or TGF-beta.
ORGANISM(S): Mus musculus 
Naive CD4+ CD62L+ CD25- T cells were differentiated under TH1 and TH2 conditions for 7 days, restimulated with anti-CD3 and anti-CD28 for 24h and sorted for IFN-gamma (TH1) and IL-4 (TH2) production using cytokine secretion assays.
ORGANISM(S): Mus musculus 
Imd, Basket and Relish (the Drosophila JNK and NF-kB homolog, respectively) genes were knock-downed individually by RNAi, and we compared the gene expression patterns in response to LPS with those of control samples treated with luciferase RNAi.
ORGANISM(S): Drosophila melanogaster 
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