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MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
UnknownMechanistic Transformation of CuI Nanoparticles Into Oxidation-Resistant 2D Copper Nanoplates.
Unconventional phase transformations reveal new crystallization mechanisms, yet direct observation of such pathways during nanoscale solution-phase synthesis remains challenging. This study uncovers an atypical growth process in which thermodynamically stable CuI nanoparticles (NPs) transform into h...
S-EPMC12757985 | biostudies-literature
UnknownImpact of implant surface type on breast cancer relapse after breast reconstruction: propensity score-matched study.
Not available
S-EPMC10480036 | biostudies-literature
UnknownEnhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules.
Adoptive cell therapy (ACT) with antigen-specific T cells is a promising treatment approach for solid cancers. Interleukin-2 (IL-2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL-2 in combination with ACT is greatly limited by short exposure and high toxi...
S-EPMC9842027 | biostudies-literature
Unknownp34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.
PTEN is one of the most frequently mutated or deleted tumor suppressors in human cancers. NEDD4-1 was recently identified as the E3 ubiquitin ligase for PTEN; however, a number of important questions remain regarding the role of ubiquitination in regulating PTEN function and the mechanisms by which ...
S-EPMC3857621 | biostudies-literature
UnknownKASL clinical practice guidelines for the management of metabolic dysfunction-associated steatotic liver disease 2025.
Not available
S-EPMC11925433 | biostudies-literature
UnknownEpigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.
The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic potentials. To understand the role of microRNAs ...
S-EPMC7509080 | biostudies-literature
UnknownThe genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.
We report the complete genome sequence of Zymomonas mobilis ZM4 (ATCC31821), an ethanologenic microorganism of interest for the production of fuel ethanol. The genome consists of 2,056,416 base pairs forming a circular chromosome with 1,998 open reading frames (ORFs) and three ribosomal RNA transcri...
S-EPMC6870993 | biostudies-literature
UnknownERα-associated translocations underlie oncogene amplifications in breast cancer.
Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1-3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplifications in breast cancer freque...
S-EPMC10307628 | biostudies-literature
UnknownEstablishment and Characterization of Immortalized Miniature Pig Pancreatic Cell Lines Expressing Oncogenic K-RasG12D.
In recent decades, many studies on the treatment and prevention of pancreatic cancer have been conducted. However, pancreatic cancer remains incurable, with a high mortality rate. Although mouse models have been widely used for preclinical pancreatic cancer research, these models have many differenc...
S-EPMC7700231 | biostudies-literature
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