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ProteomicsOpen-Gate Mutants of the Mammalian Proteasome Show Enhanced Ubiquitin-Conjugate Degradation
When in the closed form, the axial substrate translocation channel of the proteasome core particle (CP) is topologically blocked by the convergent N-termini of subunits. To probe the role of channel gating in mammalian proteasomes, we have deleted the N-terminal tail of 3. The resulting 3N proteaso...
ORGANISM(S): Homo sapiens (Human) 
2016-03-01 | PXD003577 | Pride
Proteasome Proteomics Gate Tau Oxidative stress Aggregation 
ProteomicsHuman HeLa cell lince SILAC
The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic protein
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080791 | MassIVE
MetabolomicsThe Green Tea Modulates Large Intestinal Microbiome and Exo/Endogenous Metabolome altered through Chronic UVB-exposure (Endogenous assays)
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbi...
2018-09-14 | MTBLS527 | MetaboLights
ProteomicsHuman HeLa cell lince SILAC - The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins
The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic protein
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003813 | Pride
Autophage Pca N-end rule 
TranscriptomicsscATAC-seq of mouse Plasmodium-specific CD4+ T cells
Plasmodium-specific CD4+ T cells from mice infected with Plasmodium chabaudi chabaudi AS parasites were recovered at Days 0, 4, 7, and 32 to undergo processing and to generate scATAC-seq dataset. At Day 7, CXCR5+ and CXCR6+ cells were recovered separately. At Day 32, mice were administered with eith...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9402 | biostudies-arrayexpress
GenomicsCombined RNA-seq and Polr2a ChIP-seq Identifies Gene Targets for Transcriptional Regulation in Vasopressin-Sensitive Collecting Duct Cells
In mammals, the peptide hormone vasopressin controls renal water excretion, largely through its actions in the renal collecting duct to regulate the molecular water channel aquaporin-2 (AQP2). There are two modes of regulation: 1) short-term regulation by membrane trafficking; and 2) long-term regu...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-79573 | biostudies-arrayexpress
ProteomicsCholesterol binding to VCAM-1 promotes vascular inflammation
Hypercholesterolemia has long been implicated in endothelial cell (EC) dysfunction, but the mechanisms by which excess cholesterol causes vascular pathology are incompletely understood. Here we used a cholesterol-mimetic probe to map cholesterol-protein interactions in primary human ECs and discover...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000099325 | MassIVE
TranscriptomicsRegulation of Angiogenesis by EZH2
While VEGF-targeted therapies are showing promise in clinical studies, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homologue 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in ...
ORGANISM(S): Homo sapiens 
2010-10-12 | E-GEOD-20381 | biostudies-arrayexpress
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