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ProteomicsXenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy
Inevitable need for basement membrane extract (BME) with undefined constituents, such as Matrigel, for intestinal stem cell (ISC) culture in traditional system poses a significant barrier that must be overcome for the development of clinical-grade, scalable, ready-to-use ISCs. Here, we propose a fun...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD050747 | Pride
Intestinal tissue repair Intestinal stem cell derived from 3d human intestinal organoids (isc3d-hio) Stock banking system Xenogeneic-free culture Functional polymer coating 
ProteomicsDisruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
Nuclear barrier Cellular senescence Replicative senescence Eukaryotic aging Nucleocytoplasmic trafficking 
UnknownRed ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells.
Not available
S-EPMC12365556 | biostudies-literature
TranscriptomicsE14RNA-seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. Gene expression profiles were analyzed for wild-type and Ctbp2-knockdown ESCs at both fferentiated(+LIF) and undifferentiated(-LIF) state.
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2030 | biostudies-arrayexpress
GenomicsChIP_seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. We mapped the genome-wide occupancy of Ctbp2 by ChIP-seq in mESC (E14).
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-2002 | biostudies-arrayexpress
UnknownEvaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Not available
S-EPMC10238525 | biostudies-literature
UnknownGenome-wide association identifies novel ROP risk loci in a multiethnic cohort.
Not available
S-EPMC10794688 | biostudies-literature
UnknownMulti-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.
Not available
S-EPMC9925385 | biostudies-literature
UnknownThe Contemporary Prevalence of Diabetic Neuropathy in Type 1 Diabetes: Findings From the T1D Exchange.
Not available
S-EPMC7085805 | biostudies-literature
UnknownWhole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.
Not available
S-EPMC11138106 | biostudies-literature
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