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UnknownSurvival outcomes of young-age female patients with early breast cancer: an international multicenter cohort study.

Background

The incidence of breast cancer among young Asian women is increasing, yet they remain underrepresented in global data. We analyzed the epidemiology and outcomes of Asian patients with breast cancer <40 years old across different subtypes to identify their clinical unmet needs.

...

S-EPMC11530587 | biostudies-literature
UnknownAssessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019.

Background

Health-care needs change throughout the life course. It is thus crucial to assess whether health systems provide access to quality health care for all ages. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019), we measured the Healthcare Acc...
S-EPMC9666426 | biostudies-literature
UnknownEvolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan.

Objectives

The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016.

Methods

Clinical information and data of anti-HAV ant...
S-EPMC5643057 | biostudies-literature
UnknownLow-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.
Objective: Lower serum low-density lipoprotein cholesterol (LDL-C) levels are associated with increased intracerebral hemorrhage (ICH) risk. However, reverse causality and residual confounding has not attracted public attention. Therefore, we assessed whether people with LDL-C have increased ...
S-EPMC8802633 | biostudies-literature
UnknownCentral obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.

Background

Central obesity is a rising epidemic, and often occurs in parallel with dyslipidemia. Furthermore, enhancement of ectopic fat deposition has been observed in both human studies and animal models of altered lipidemic control. Though APOA1/C3/A4/A5 genetic polymorphisms are associat...
S-EPMC3608892 | biostudies-literature
UnknownIntegrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

Purpose

Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeu...
S-EPMC4062710 | biostudies-literature
UnknownEffects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study.

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the effect of this deletion on the clinical feat...
S-EPMC7434477 | biostudies-literature
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
UnknownAssociation of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study.

Background

Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available.

Methods

We conducted an observ...
S-EPMC8027908 | biostudies-literature
UnknownHeterologous booster vaccination with CoronaVac following prime vaccination with mRNA vaccine.

Objective

Despite the high vaccine efficacy of mRNA COVID-19 vaccines, there are individuals who developed excessive reactogenic and/or allergic responses after the first mRNA dose and were considered ineligible for further mRNA doses. CoronaVac, an inactivated SARS-CoV-2 vaccine, is recomme...
S-EPMC9398778 | biostudies-literature
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