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TranscriptomicsAnalysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells
Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analysed the transcriptome profile o...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-32902 | biostudies-arrayexpress
TranscriptomicsTranscriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumours are generally benign. However, many are invasive and some of these are aggressive with high proliferation and recurrence rates. Only metastatic tumours are considered malignant and are rare (0.2%). To identify molecular events associated with the aggressive and malignant phenotypes...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22812 | biostudies-arrayexpress
TranscriptomicsGenomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor ...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22615 | biostudies-arrayexpress
TranscriptomicsTranscriptional and post-transcriptional analysis of CD4+ T cell clones deriving from HTLV-1 infected individuals
T-cell clones were obtained by limiting dilution culture of PBMC of HTLV-1 carriers. Exon expression profiling was performed using Affymetrix exon array (Affymetrix Human Exon 1.0 ST Array) according to the manufacturer's instructions. The main objectives were to assess whether transcriptional and p...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-46518 | biostudies-arrayexpress
TranscriptomicsAnalysis of the early transcriptome signature of infection of primary endothelial cells by Nipah virus vs. Nipah virus deleted for the expression of non-structural C protein
Nipah virus (NiV) is a highly pathogenic, negative strand RNA paramyxovirus that has recently emerged from flying foxes to cause serious human disease. To study the poorly-understood role of nonstructural NiV proteins in NiV pathogenesis, we generated recombinant viruse lacking the expression of acc...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-33133 | biostudies-arrayexpress
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