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TranscriptomicsTransciptional profile of a M. smegmatis mc2155 ΔsigF strain under standard growth conditions
Comparing transciptional profile of a M. smegmatis mc2155 ΔsigF strain and wild type (control) in in vitro culture at two time points (exponential phase and stationary phase) for identification of SigF-dependent genes. Analysis of 2 time points: exponential and stationary phase. 4 biological replic...
ORGANISM(S): Mycobacterium smegmatis 
2010-06-05 | E-GEOD-19145 | biostudies-arrayexpress
ProteomicsThe natural diversity of the yeast proteome links aneuploidy tolerance to genome-wide proteome
Recent advancements in genome sequencing have facilitated accessing the natural genetic diversity of species, unveiling hidden genetic traits, clarifying gene functions, and the degree to which laboratory studies can be generalized. One notable discovery is the frequent (~20%) aneuploidy - an imbala...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-11 | PXD044526 | Pride
Large-scale Proteomics Lab-engineered strains Yeast Diversity Wild isolates High-throughput Aneuploidy 
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
ModelsSobotta2017 - IL-6-induced JAK1-STAT3-signaling
Here we present a mathematical model of IL-6-induced JAK1-STAT3 signaling that quantitatively links physiological IL-6 concentrations to the dynamics of IL-6-induced signal transduction and expression of target genes in hepatocytes. The mathematical model consists of coupled ordinary differential eq...
2023-07-05 | MODEL2307050001 | BioModels
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