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TranscriptomicsSaccharomyces cerevisiae deletion collections chemogenomic screen with sr7575
Growth assay in the presence of a toxic chemical (sr7575) that uses the barcoded collections of yeast gene deletions (haploid, diploid, DamP) to identify deletion strains that are hypersensitive to the drug. Two-condition experiment – growth of a pool of strains in the presence or absence of the d...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-09 | E-GEOD-60934 | biostudies-arrayexpress
ProteomicsUnbiased mapping of human cerebrospinal fluid proteome dynamics
Our purpose is to explore the dynamics of a clinically relevant proteome by determining protein turnover, synthesis and breakdown. ]. The alteration of protein turnover represents a new type of biological information which might provide unique insight in disease pathophysiology, e.g. Alzheimer disea...
ORGANISM(S): Homo sapiens (Human) 
2020-01-22 | PXD012462 | Pride
Dynamics Human Csf Protein 
ProteomicsUnbiased mapping of human cerebrospinal fluid proteome dynamics - Profile data
Our purpose is to explore the dynamics of a clinically relevant proteome by determining protein turnover, synthesis and breakdown. ]. The alteration of protein turnover represents a new type of biological information which might provide unique insight in disease pathophysiology, e.g. Alzheimer disea...
ORGANISM(S): Homo sapiens (Human) 
2020-01-22 | PXD012502 | Pride
Ms1 profile data 
GenomicsSaccharomyces cerevisiae
Saccharomyces cerevisiae deletion collections chemogenomic screen with sr7575
PRJNA259859 | ENA
TranscriptomicsGenetic heterogeneity versus molecular analysis of prion susceptibility in neuroblasma N2a sublines
The neuroblastoma-derived cell line N2a is permissive to certain prion strains but resistant sublines unable to accumulate the pathological proteinase-K resistant form of the prion protein can be isolated. We compared for gene expression and phenotypes different N2a sublines that were susceptible or...
ORGANISM(S): Mus musculus 
2010-06-19 | E-GEOD-5374 | biostudies-arrayexpress
TranscriptomicsMicroarray data for rejuvenation experiments through reprogramming
Proliferative and replicative senescent fibroblasts from aged human donors were reprogrammed towards pluripotency and re-differentiated in fibroblasts and then further analyzed for rejuvenation assessment. Comparison of microarrays were performed by non hierarchical clustering visualized in with Tre...
ORGANISM(S): Homo sapiens 
2011-12-14 | E-GEOD-27924 | biostudies-arrayexpress
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in plasma using High Resolution mass spectrometry (MS). This labeling approach could be of great interest for monitoring many leucine-co...
ORGANISM(S): Homo Sapiens 
2025-11-10 | PXD046373 | panorama
ProteomicsModeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in human in vivo
The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net...
ORGANISM(S): Homo Sapiens 
PXD047851 | panorama
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) and in plasma using targeted mass spectrometry (MS). This labeling approach could be of great interest for ...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD046142 | panorama
ProteomicsTau Profiling of Brain Extracellular Vesicles Reveals PHF6 Peptide as Core for Pathological Tau Seeding in Alzheimer's Disease
EVs are bilipid spheres known for their role in cellular communication through transport of proteins, lipids, RNA and more. In the brain, EVs are directly released in the interstitial fluid surrounding neural cells and hence entitled brain-derived EVs (BD-EVs). Human BD-EVs of AD patients contain se...
ORGANISM(S): Homo Sapiens 
PXD067593 | panorama
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