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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsNascent glycoproteome reveal the suppressed expression of glycosylated LAMP2 in response to N-linked glycosylation inhibition
(1) Analysis of newly synthesized proteins under glycosylation inhibition (2) Analysis of newly synthesized glycoproteins during NGI-1 treatment
ORGANISM(S): Homo Sapiens 
2021-09-04 | PXD028212 |
ProteomicsNascent proteome and glycoproteome reveal the inhibition role of ALG1 in hepatocellular carcinoma cell migration
(1) ALG1-related changes of the nascent proteome in Huh7 cell line (2) Knockdown of ALG1 inhibited the expression of glycosylated N-cadherin
ORGANISM(S): Homo Sapiens 
2021-10-11 | PXD029045 |
ProteomicsN-glycopeptide Signatures in AFP-negative HCC
Serum N-linked intact glycopeptides was investigated in AFP-negative HCC and cirrhosis (LC) patients by using label-free quantification methodology.
ORGANISM(S): Homo Sapiens 
2021-01-11 | PXD023500 |
ProteomicsProteomic landscape of plasma and plasma-derived sEVs and lEVs in uveitis and posterior scleritis
Uveitis and posterior scleritis are sight-threatening diseases with undefined pathogenesis, accurate diagnosis remains challenging. Here, two plasma-derived extracellular vesicle (EV) subpopulations, small and large EVs, were obtained from patients with uveitis and posterior scleritis and subjected ...
ORGANISM(S): Homo Sapiens 
2022-09-19 | PXD036844 |
ProteomicsThe research of RBM39 in multiple myeloma
RBM39 is a RNA binding protein, we aim to investigate its role in multiple myeloma. We performed mass spectrometry of RBM39 interacted protein obtained by IP.
ORGANISM(S): Homo Sapiens 
2025-02-09 | PXD060610 |
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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