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MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
TranscriptomicsIron uptake controls the generation of Leishmania infective forms through regulation of ROS levels .
During its life cycle Leishmania undergoes extreme environmental changes, alternating between insect vectors and vertebrate hosts. In mammals the parasites replicate within parasitophorous vacuoles of macrophages, compartments that contain low concentrations of iron. Here we show that stimulation of...
ORGANISM(S): Leishmania amazonensis 
2012-12-15 | E-GEOD-41641 | biostudies-arrayexpress
ProteomicsThe mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to ma...
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2018-10-11 | MSV000083023 | MassIVE
TranscriptomicsDistinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes
To determine the modulation of gene expression of C57BL/6 and DBA/2 BMDLs in the presence of living intracellular Leishmania amazonensis amastigotes A genome-wide transcriptional analysis was performed by comparing the gene expression profiles of control DLs and live amastigote-hosting DLs from bot...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-38261 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Leishmania mexicana wild type and glucose transporter (lmgt) knock-out strains show genomic adaptation
Genomic adaptation following glucose transporter knockout in leishmania mexicana
ORGANISM(S): Leishmania mexicana 
2008-12-01 | E-MEXP-1858 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
We used Illumina sequencing of poly-A selected RNA of Leishmania mexicana (WHO strain MNYC/BZ/62/M379) culture-adapted promastigotes (PRO), axenic amastigotes (AXA) and intracellular amastigotes (AMA) in mouse bone marrow derived macrophages (BMDM), 24h after infection, to map 5' and 3' ends of Leis...
ORGANISM(S): Leishmania mexicana 
2015-09-11 | E-MTAB-3312 | biostudies-arrayexpress
GenomicsLeishmania amazonensis
Leishmania amazonensis Transcriptome or Gene expression
PRJNA292915 | ENA
TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania amazogensis amastigotes
L. amazonensis (LV79 strain, ref.: MPRO/BR/1972/M1841) amastigotes were added or not to BALB/c mouse bone marrow-derived macrophage cultures at a multiplicity of 4 per macrophage. Parasite-harboring macrophages (samples I1 and I2) and parasite-free ones (samples (UI1 and UI2) were cultured at 34M-0C...
ORGANISM(S): Mus musculus 
2009-01-01 | E-MEXP-1595 | biostudies-arrayexpress
ProteomicsComparative membrane-associated proteome of Leishmania (Leishmania) infantum and L.(L.) amazonensis
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. (L.) infantum and L. (L.) amazonensis are causative agents of visceral and cutaneous leishmaniasis, respectively. Most proteome analyses o...
ORGANISM(S): Leishmania infantum JPCM5 Leishmania mexicana 
2022-02-11 | PXD013087 | Pride
Label free proteomics Plasma membrane proteins Leishmania (leishmania) infantum Leishmania (leishmania) amazonensis 
GenomicsLeishmania amazonensis
GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis
PRJNA135277 | ENA
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