Dataset Information
Comparative genomic hybridization of Leishmania mexicana wild type and glucose transporter (lmgt) knock-out strains show genomic adaptation
Ontology highlight
ABSTRACT:
ORGANISM(S): Leishmania mexicana
SUBMITTER: Stephen Beverley
PROVIDER: E-MEXP-1858 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.
Molecular microbiology 20081110 2
A glucose transporter null mutant of the parasitic protozoan Leishmania mexicana, in which three linked glucose transporter genes have been deleted by targeted gene replacement, is unable to replicate as amastigote forms within phagolysomes of mammalian host macrophages and is avirulent. Spontaneous suppressors of the null mutant have been isolated that partially restore replication of parasites within macrophages. These suppressor mutants have amplified the gene for an alternative hexose transp ...[more]
