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TranscriptomicsEstrogen-modulated gene expression in c-kit+ stem cells and CD44+ stromal cells
The recent interest in the role of bone marrow derived endothelial progenitor cells in the benefits of estrogen on cardiovascular health brought us to evaluate if estrogen could affect cardiac repair more broadly by regulating biological processes involved in the functional organization of the bone ...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-9098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast wild type and Pab2 knockout strains to invstigate the role of Pab2 in synthesis of noncoding snoRNAs
Here we used DNA microarrays to identify hyperadenylated transcripts detected in pab2 cells. Using this genome-wide approach, we found that the absence of Pab2 leads to the accumulation of polyadenylated snoRNAs and we describe the molecular mechanism of their accumulation.
ORGANISM(S): Schizosaccharomyces pombe 
2010-01-21 | E-TABM-843 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of yeast FBY107, FBY106 strains to investigate pre-mRNA degradation pathway
General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a nuclear pre-mRNA degradation pathway that controls the expression of select intron-containing genes. We show that the fissi...
ORGANISM(S): Schizosaccharomyces pombe 
2012-02-10 | E-MTAB-708 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of human adult peripheral blood populations
Generate transcriptomic atlas of healthy peripheral blood subpopulations RNA-Seq performed on sorted granulocytes, monocytes, B-cells, T-cells, total WBC, CD34+ cells Leucegene Project, IRIC
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-51984 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of primary AML specimens exposed to AhR modulating agents
The goal of the study was to identify genes that are directly or indirectly coregulated by the AhR pathway in primary human AML cells. Patient AML cells were treated for 16 hours with the two indirubin derivatives 6-bromoindirubin-3'oxime (BIO), 1-Methyl-6-bromoindirubin-3'oxime (MeBIO), the AHR-ant...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-48843 | biostudies-arrayexpress
TranscriptomicsLeucegene: AML sequencing (part 4)
RNA sequencing of human leukemia The goals of this project are to obtain a comprehensive study of mutations and gene expression in human acute myeloid leukemia (AML). Methods: AML cells were thawed. DNA and RNA (polyA) was extracted and sequences were obtained with an illumina HiSeq 2000 sequencer. ...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-66917 | biostudies-arrayexpress
TranscriptomicsLeucegene: AML sequencing (part 5)
RNA sequencing of human leukemia The goals of this project are to obtain a comprehensive study of mutations and gene expression in human acute myeloid leukemia (AML). Methods: AML cells were thawed. DNA and RNA (polyA) was extracted and sequences were obtained with an illumina HiSeq 2000 sequencer. ...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-67039 | biostudies-arrayexpress
TranscriptomicsLeucegene: AML sequencing (part 3)
RNA sequencing of human leukemia The goals of this project are to obtain a comprehensive study of mutations and gene expression in human acute myeloid leukemia (AML). Methods: AML cells were thawed. DNA and RNA (polyA) was extracted and sequences were obtained with an illumina HiSeq 2000 sequencer. ...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-62190 | biostudies-arrayexpress
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