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ProteomicsEPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization
Polycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to PRC2.1, which also contains PCL proteins. Unlike other accessory subunits that collectively facilitate PRC2 targeting, EPOP was i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-20 | PXD072233 | Pride
ProteomicsConfetti: A Multi-protease Map of the HeLa Proteome for Comprehensive Proteomics
Tryptic digestion proteomics gives limited coverage of many protein sequences as many proteins produce tryptic peptides that cannot be observed easily. Confetti is our comprehensive map of coverage for the HeLa proteome, using 48 different digests and CID/HCD LC-MS/MS analyses. An associated dataset...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-10-12 | MSV000081607 | MassIVE
ProteomicsA programmed decline in ribosome levels governs human early neurodevelopment
How reductions in ribosome biogenesis can result in tissue- and developmental-specific defects remain a mystery. Here we describe allelic variants in the ribosome biogenesis factor AIRIM/C1orf109 that are primarily associated with neurodevelopmental disorders. Using human cerebral organoids in combi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD063298 | Pride
Tmtpro 18plex Ribosome Mtor 
ProteomicsIdentification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Malaria remains a global health threat as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-30 | PXD053252 | Pride
Plasmodium Drug discovery Malaria Drug resistance Proteasome 
ProteomicsIdentification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Malaria remains a global health threat as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-30 | PXD052762 | Pride
Plasmodium Drug discovery Malaria Drug resistance Proteasome 
ProteomicsSimultaneous selection of nanobodies for immune epitopes in the complex tumor microenvironment
In the rapidly advancing field of synthetic biology, there is a critical need for technology to discover targeting moieties for therapeutic biologics. We developed INSPIRE-seq, an approach that utilizes a nanobody library and next-generation sequencing to identify nanobodies selected for complex env...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046363 | Pride
Phage Nanobodies Immune cells 
ProteomicsIdentification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Malaria remains a global health threat as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-30 | PXD052830 | Pride
Plasmodium Drug discovery Malaria Drug resistance Proteasome 
OtherConfetti: A Multi-protease Map of the HeLa Proteome for Comprehensive Proteomics
Data from ProteomeXchange, PXD ID: PXD000900. Data file: HeLa_ArgC-Elastase_CID_2.mgf. Published as part of Mol Cell Proteomics. 2014 Apr 2 . From the Abstract: {{i}} ... In an attempt to improve protein sequence coverage and to target regions of proteins that do not generate useful tryptic peptide...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210026998 | GPMDB
Resource Reanalysis 
OtherConfetti: a multiprotease map of the HeLa proteome for comprehensive proteomics.
Data from ProteomeXchange, PXD ID: PXD001258. Experiment: Hela_Try_80pcACN_CID_3xload, file: Hela_Try_80pcACN_CID_3xload_3_20140722.mzXML. Information serves as a correction to Mol Cell Proteomics. 2014 Jun;13(6):1573-84 . From ProteomeXchange: {{i}} Contains corrected HeLa SAX fractionated dataset...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320002604 | GPMDB
Resource Reanalysis 
ProteomicsAnnexin A2-dependent extracellular vesicle proteome modulates pre-metastatic stromal fibroblast behavior in triple-negative breast cancer
Proteomic profiling of AnxA2-enriched extracellular vesicles from MDA-MB-4175 triple-negative breast cancer cells
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD067600 | Pride
Annexin a2 Stromal remodeling Knockdown Extracellular vesicles Fibroblast migration Proteomic profiling Tumor microenvironment Triple-negative breast cancer Metastasis 
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