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ProteomicsmiR-122-dependent binding of TNRC6 to HCV RNA
The liver-specific microRNA, miR-122, is an essential host factor for replication of hepatitis C virus (HCV), an important infectious cause of chronic liver disease and hepatocellular carcinoma. miR-122 stabilizes the positive-strand HCV RNA genome and promotes viral RNA synthesis by binding two clo...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD013054 | Pride
Ap-ms Risc complex Protein translation Rna stability Microrna 
ProteomicsHepatovirus translation requires PDAP1, an eIF4E-binding protein regulating ER stress responses
The overexpression and misfolding of viral proteins in the endoplasmic reticulum (ER) may cause cellular stress, thereby inducing cytoprotective proteostatic host responses involving phosphorylation of eIFa. Here, we show the positive-strand RNA virus responsible for infectious hepatitis adopts a st...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052233 | Pride
Hepatovirus Lc-ms Pdap1 Eifa 
ProteomicsThe hepatovirus pX protein contains ancient signals for ESCRT-dependent capsid quasi-envelopment
Hepatoviruses, a common cause of acute hepatitis in humans, are atypical picornaviruses released from cells in small vesicles resembling exosomes. We show the nonlytic release of these quasi-enveloped virions is mediated by a C-terminal extension of the VP1 capsid protein (pX) that binds the Bro1 do...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD022107 | Pride
Hepatovirus px Lc-ms 
TranscriptomicsMicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity ...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-41737 | biostudies-arrayexpress
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
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