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ProteomicsHepatovirus translation requires PDAP1, an eIF4E-binding protein regulating ER stress responses
The overexpression and misfolding of viral proteins in the endoplasmic reticulum (ER) may cause cellular stress, thereby inducing cytoprotective proteostatic host responses involving phosphorylation of eIFa. Here, we show the positive-strand RNA virus responsible for infectious hepatitis adopts a st...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052233 | Pride
Hepatovirus Lc-ms Pdap1 Eifa 
GenomicsPDAP1 RIP in UV-crosslinked human T cells
PDAP1 RIP in UV-crosslinked human T cells
PRJNA761680 | ENA
GenomicsGene expression comparison, WT and PDAP1-deficient primary B lymphocytes
Gene expression comparison, WT and PDAP1-deficient primary B lymphocytes
PRJNA595013 | ENA
OtherPDAP1 RIP in UV-crosslinked human T cells
Human CD4+ Total memory cells (CD4+CD25-CD45RA-CCR7+/-) were activated for 5d with anti-CD3/anti-CD28 antibodies. About 40*10^6 cells were then irradiated twice with 254nm UV light at 0.2J and then lysed in RIPA buffer. 1mg of cell extract was incubated on a rotating wheel ~16 h at 4°C with anti-PDA...
ORGANISM(S): Homo sapiens 
2022-01-10 | GSE183685 | GEO
TranscriptomicsGene expression comparison, WT and PDAP1-deficient primary B lymphocytes
Class switch recombination (CSR) and somatic hypermutation (SHM) are antibody gene diversification reactions occurring in mature B cells that are essential for protective humoral immunity. CSR and SHM are initiated following activation by the antigen, and are dependent on efficient induction of acti...
ORGANISM(S): Mus musculus 
2020-06-19 | GSE141876 | GEO
UnknownIdentifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study.
Not available
S-EPMC12266772 | biostudies-literature
UnknownRFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.
Not available
S-EPMC8865640 | biostudies-literature
UnknownPDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.
Not available
S-EPMC9395323 | biostudies-literature
UnknownPDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Not available
S-EPMC7537392 | biostudies-literature
UnknownHepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responses.
Not available
S-EPMC11578187 | biostudies-literature
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