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TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from HIV patients vs uninfected controls suggest that monocyte function is diminished during high-level HIV viremia and that this effect is mediated by chronic stimulation by type I interferons
The effect of human immunodeficiency virus (HIV) infection and high-level HIV replication on the function of monocytes was investigated. HIV-positive patients had elevated levels of spontaneous production of some or all of the monocyte proinflammatory cytokines measured (interleukin-1beta [IL-1beta]...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5220 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway
IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44732 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in a Rabbit Model of Systemic Lupus Erythematosus
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystag...
ORGANISM(S): Oryctolagus cuniculus 
2010-07-23 | E-GEOD-23076 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells before and after vaccination with human papilloma virus-like particle
Human papilloma (HPV) virus-like particle (VLP) vaccines were recently licensed. Though neutralizing antibody titers are thought to be the main effectors of protection against infection, early predictors of long-term efficacy are not yet defined and a comprehensive understanding of innate and adapt...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-13587 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 treated human macrophages induce the expression of novel miRNAs which may mediate anti-viral properties (RNA-seq)
In this study, we hypothesized that IL-27 could induce the expression of novel miRNAs in macrophages which may have functional relevance in terms of anti-viral activity. In this study, primary monocytes were differentiated into macrophages using M-CSF (M-Mac) or with a combination of M-CSF and IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44953 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 treated human macrophages induce the expression of novel miRNAs which may mediate anti-viral properties (affy)
In this study, we hypothesized that IL-27 could induce the expression of novel miRNAs in macrophages which may have functional relevance in terms of anti-viral activity. In this study, primary monocytes were differentiated into macrophages using M-CSF (M-Mac) or with a combination of M-CSF and IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44955 | biostudies-arrayexpress
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