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TranscriptomicsCharacterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
To identify genes expressed during initiation of lung organogenesis, we generated transcriptional profiles of the prospective lung region of the mouse foregut (mid-foregut) microdissected from embryos at three developmental stages between embryonic day 8.5 (E8.5) and E9.5. This period spans from lun...
ORGANISM(S): Mus musculus 
2010-01-14 | E-GEOD-19873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hela cells treated with the topoisomerase poison camptothecin
Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. The response of tumor cells to the unusual form of DNA damage caused by topoisomerase poisons such as camptothecin (CPT) is poorly understood, and knowledge regarding which drugs can be effecti...
ORGANISM(S): Homo sapiens 
2007-07-29 | E-GEOD-1417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fat samples from gastric bypass patients
Fat tissue was resected during gastric bypass surgery for management of obesity. All subjects had fasted at least 10 hours before surgery. Subjects with malignancies were excluded. No subjects were taking thiazolidinediones or steroids. None had fasting plasma glucose levels over 120 mg/ dl. One ha...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-1657 | biostudies-arrayexpress
TranscriptomicsA gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. METHODS: In order to gain insights into the molecular pathways underlying prog...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-27597 | biostudies-arrayexpress
TranscriptomicsCritical role of the hydrogen peroxide-responsive nuclear kinase CK1-alpha-LS in vascular cell activation
CK1-alpha-LS was knocked down in human coronary artery smooth muscle cells. Gene level and exon level changes in expression were assessed. CK1-alpha-LS was knocked down in human coronary artery smooth muscle cells using retrovirus containing shRNA targeting the alternatively spliced L-insert.
ORGANISM(S): Homo sapiens 
2010-12-11 | E-GEOD-19441 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-4423 as a Primate-Specific microRNA Highly Expressed in Ciliated Airway Epithelium and Associated with Lung Cancer [Affymetrix]
Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. While microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with lung cancer in these cells remains unknown. Here, we ...
ORGANISM(S): Homo sapiens 
2013-10-08 | E-GEOD-48796 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression associated with emphysematous lung destruction
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by varying degrees of emphysematous lung destruction and small airway disease, each with distinct effects on clinical outcomes. There is little known about how microRNAs contribute specifically to the e...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-49881 | biostudies-arrayexpress
TranscriptomicsValidation of an Airway Gene Expression Classifier for Lung Cancer in Patients Undergoing Diagnostic Bronchoscopy
BACKGROUND: In patients with suspicious pulmonary lesions, bronchoscopy is frequently non-diagnostic. This often results in additional invasive testing, including surgical biopsy, although many patients have benign disease. We sought to validate an airway gene-expression classifier for lung cancer ...
ORGANISM(S): Homo sapiens 
2015-05-17 | E-GEOD-66499 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-4423 as a Primate-Specific microRNA Highly Expressed in Ciliated Airway Epithelium and Associated with Lung Cancer [high throughput sequencing]
Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. While microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with lung cancer in these cells remains unknown. Here, we ...
ORGANISM(S): Homo sapiens 
2013-10-08 | E-GEOD-32726 | biostudies-arrayexpress
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