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ProteomicsPeptide and MUC5B hydrolysis by the Mucin Degrading Protease (MdpL) from Limosilactobacillus fermentum
MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the pro...
ORGANISM(S): Homo sapiens (Human) 
2023-03-22 | PXD039681 | Pride
Iob Mdpl Limosilactobacillus fermentum Muc5b Neuromedin Mog Lc-msms 
ProteomicsMdpS and MdpS2 structurally and functionally diverge to regulate Streptococcus oralis mucin degradation
The human oral cavity harbors a diverse microbial community, with oral streptococci, particularly the Streptococcus mitis group, playing a pivotal role in biofilm formation and oral health. Among these, Streptococcus oralis is a key early colonizer that stabilizes oral biofilms. Here, we identify tw...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062603 | Pride
Muc5b Streptococcus oralis Biofilm dynamics Mucin degrading proteases Oral microbiome Mucin degradation 
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