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Background: As the most stable and experimentally accessible epigenetic mark, DNA methylation is of great interest to the research community. The landscape of DNA methylation across tissues, through development and in disease pathogenesis is not yet well characterised. Thus there is a need for rapid...
ORGANISM(S): Homo sapiens 
Methylarginine degrons mark proteins for degradation in lysosomes. We leveraged the machinery responsible for methylarginine degron addition to create a chemically inducible degrader named a Methyl Arginine Targeting Chimera (MrTAC). First, we evaluated the contents of isolated lysosomes following a...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD071805 | Pride
The dataset set consists of 295 microarrays from 121 individual CHO cultures producing a range of biologics including monoclonal antibodies, fusion proteins and therapeutic factors; non-producing cell lines were also included. Samples were taken from a wide range of process scales and formats that v...
ORGANISM(S): Cricetulus griseus 
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
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