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TranscriptomicsLet-7 microRNAs are developmentally regulated in circulating human erythroid cells
MicroRNA are ~22nt-long small non-coding RNA that negatively regulate protein expression through mRNA degradation or translational repression in eukaryotic cells. Based upon their importance in regulating development and terminal differentiation in model systems, erythrocyte microRNA profiles were e...
ORGANISM(S): Human herpesvirus 4 
2010-06-21 | E-GEOD-17405 | biostudies-arrayexpress
TranscriptomicsInactivation of the exosome ribonuclease DIS3 triggers the pluripotency factor LIN28B, repressing let-7 miRNAs and unleashing MYC and RAS.
Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanc...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-55246 | biostudies-arrayexpress
TranscriptomicsLet-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy
Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway, which is the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and cat...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-60452 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of glial progenitor cells in growth and differentiation conditions
The molecular basis of astrocyte differentiation and maturation is poorly understood. As microRNAs have important roles in cell fate transitions, we set out to study their function during the glial progenitor cell (GPC) to astrocyte transition. Inducible deletion of all canonical microRNAs in GPCs i...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-64661 | biostudies-arrayexpress
MetabolomicsFunctional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary ability to restore a wide variety of damaged structures by a process denominated epimorphosis. While the origin and potentiality of progenitor cells that take part during epimorphic regeneration are known to ...
2021-11-04 | MTBLS1708 | MetaboLights
Genomicssecondary structure based on icSHAPE of pre-let-7 and hDicer-TRBP bound pre-let-7
secondary structure based on icSHAPE of pre-let-7 and hDicer-TRBP bound pre-let-7
PRJNA433923 | ENA
ProteomicsThe let-7 family of miRNA mediates paternal intergenerational inheritance of metabolic disorders via post-transcriptional regulation of mitochondrial dynamics.
This study aims to investigate the molecular mechanisms and nature of impaired soma-germline crosstalk in IEI by focusing on the miRNA regulations in soma and sperm of obese male mice. We found that F0 HFD deteriorated glucose metabolism in F0 and F1, whereas F0 weight loss largely corrected glucose...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-06 | PXD042800 | Pride
Metabolic diseases Mitochondrial dysfunction Microrna Intergenerational epigenetic inheritance Let-7 
ProteomicsC/EBPβ-LIP regulates the let-7/Lin28b circuit to induce cancer-type metabolic reprogramming
The RNA binding protein Lin28b is highly expressed during embryogenesis but its expression declines in adult tissues, and aberrant expression of Lin28b is associated with tumour development and maintenance. Lin28b regulates the translation of several glycolytic and mitochondrial enzymes in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010095 | Pride
Q exactive hf Shotgun proteomics 
GenomicsDefective zebrafish heart regeneration following depletion of let-7
Defective zebrafish heart regeneration following depletion of let-7
PRJNA518758 | ENA
GenomicsLin28/let-7 axis regulates the timig of cession of nephrogenesis
Lin28/let-7 axis regulates the timig of cession of nephrogenesis
PRJNA482367 | ENA
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