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ProteomicsLabel-free quantitative proteomics analysis of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin
The present study is a pioneering investigation that has been carefully designed to study proteomic effects of specific cancer-related mutation using the lgl mutant of D. melanogaster that has not been well characterised thus far. Recent findings concerning the D. melanogaster cancer models suggest ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-05-10 | PXD033191 | Pride
Label-free quantitative proteomics Lethal giant larvae Circadian proteome Melatonin. Drosophila melanogaster 
GenomicsLethal giant larvae gene family functions as a tumor suppressor in skin epidermis
Lethal giant larvae gene family functions as a tumor suppressor in skin epidermis
PRJNA1040296 | ENA
TranscriptomicsTranscriptional profiling of neoplastically transformed and wild type wing imaginal discs of Drosophila
In Drosophila, homozygosity for tumor suppressors, like lethal giant larvae, lgl, results in neoplastic transformation of imaginal disc epithelium - characterized by loss of their apico-basal polarity, unrestricted growth and invasion into neighboring tissues/organs. In genetic mosaics, however, lgl...
ORGANISM(S): Drosophila melanogaster 
2011-06-08 | E-MEXP-2753 | biostudies-arrayexpress
UnknownEvaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate.
Not available
S-EPMC5120214 | biostudies-literature
UnknownStability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM.
Not available
S-EPMC2975158 | biostudies-literature
UnknownYeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9.
Not available
S-EPMC2199738 | biostudies-literature
UnknownOrdered multisite phosphorylation of lethal giant larvae by atypical protein kinase C.
Not available
S-EPMC4372073 | biostudies-literature
UnknownLethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle.
Not available
S-EPMC3596994 | biostudies-literature
TranscriptomicsTime Series gene expression profiling of Lethal Giant Larvae tumours in developing wings of Drosophila larvae
Cancer is a complex phenomenon involving multiple cellular pathways and processes in various combinations. As a genetic system, Drosophila has contributed much to our understanding of processes that initiate tumorigenesis. However, these are still disparate threads of information and a comprehensive...
ORGANISM(S): Drosophila melanogaster 
2021-02-18 | E-MTAB-10059 | biostudies-arrayexpress
UnknownThe cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function.
Not available
S-EPMC3666253 | biostudies-literature
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