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Transcriptomicsrewatering-Global gene expression in young differentiating xylem of poplar in response to a drought –rewatering cycle
affy_rewatering_poplar - rewatering - Biological question (15 lines max): Xylogenesis is a complex process and is highly influenced by environmental factors. Numerous studies have shown xylem structural acclimation to moderate and long-lasting water deficits. A decrease in cell lumen size and an inc...
ORGANISM(S): Populus tremula x Populus alba 
2010-06-16 | E-GEOD-20061 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bos taurus CD14+ purified bovine monoctye stimulation with CpG ODN 2007 vs. GpC ODN 2007, CpG 2007 vs. Control, GpC 2007 vs. Control and Media vs Control (
CD14+ purified bovine monoctye stimulation with CpG ODN 2007 vs. GpC ODN 2007, CpG 2007 vs. Control, GpC 2007 vs. Control and Media vs Control (Control is unstimluated CD14+ purified bovine monocytes at time zero). Before stimulation, the CD14+ purified bovine monocytes were rested for 20 h. Then t...
ORGANISM(S): Bos taurus 
2005-01-01 | E-FPMI-2 | biostudies-arrayexpress
TranscriptomicsEffect of rBTNL2.Fc co-stimulation on murine CD4+ cells
Naïve T cell activation involves at least two signals from an antigen presenting cell (APC), one through the T cell receptor via interaction with APC peptide-MHC complexes and a second through interaction of CD28 with APC B7 ligands. Following activation, T cells up-regulate a host of other membran...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-42385 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human adipose-derived stem cells to study the influence of cell-secreted ECM on the osteogenic differentiation process.
The aim of this study is to characterize how the extracellular matrix secreted by adipose-derived stem cells (ADSC) during osteogenesis affects the differentiation process. Specifically, ADSC undergo osteogenesis by following similar maturational phases as bone marrow-derived stem cells. However, it...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-MEXP-3340 | biostudies-arrayexpress
TranscriptomicsGene is expression in 2 mutant alleles of the freezing-sensitive mutant sfr6 subjected to cold.
The sfr6-1 mutant of Arabidopsis has been shown to be defective in freezing tolerance and fails to express a number of cold-regulated genes to normal wild type levels. The aim of this experiment was to test whether two other mutant alleles, sfr6-2 and sfr6-3 showed similar defects in cold-inducible ...
ORGANISM(S): Arabidopsis thaliana 
2014-12-22 | E-GEOD-46084 | biostudies-arrayexpress
TranscriptomicsNon-small-cell lung tumor and normal lung tissue methylation
Using paired tumor and non-tumor lung tissues from 47 individuals we identified common changes in DNA methylation associated with the development of non-small cell lung cancer. Pathologically normal lung tissue taken at the time of cancer resection was matched to tumorous lung tissue and together we...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-27902 | biostudies-arrayexpress
TranscriptomicsML-DmBG3-c2 Replication Timing
modENCODE_submission_670 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The relative time of replication for all unique sequences in the Drosophila genome was determined by synchronizing tissue ...
ORGANISM(S): Drosophila melanogaster 
2009-07-29 | E-GEOD-17281 | biostudies-arrayexpress
TranscriptomicsIsolation and transcriptional profiling of embryonic human neural crest cells
To identify new candidate genes for neurocristopathies, a Long-SAGE library has been made from human neural crest cells (hNCC) derived from a normal embryo at Carnegie stage 13. Data analysis indicates the expression of a number of genes in multiple GO functional classes that were anticipated based...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-8368 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of the diabetic retinal response to chronic insulin treatment
The aim of this study was to identify alterations associated with diabetes-induced functional dysregulation of the retina and the effects of chronic insulin therapy. Transcriptional profiling through microarray analysis was analyzed to find mRNA targets of interest in diabetic samples, as well as i...
ORGANISM(S): Rattus norvegicus 
2011-05-23 | E-GEOD-24423 | biostudies-arrayexpress
TranscriptomicsMulti-modal proteomic target discovery and orthogonol confirmation of preclinical diabetic retinopathy drug development biomarkers
The aim of this study was to identify proteomic alterations associated with functional dysregulation of the retina with diabetes that could eventually be used as surrogate endpoints in preclinical drug testing studies. A multi-modal approach of antibody (Luminex)-, electrophoresis (2-DIGE)-, and LC-...
ORGANISM(S): Rattus norvegicus 
2010-06-01 | E-GEOD-20886 | biostudies-arrayexpress
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