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ProteomicsROSALIND protects the mitochondrial translational machinery from oxidative damage
Cancer therapy resistance, whether pre-existing or arising upon acquisition of de novo mutations and via non-genetic adaptation, is still a clinical challenge. Multiple anticancer drugs are thought to cause cell death via increasing mitochondrial ROS which are a bioproduct of oxidative phosphorylati...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD047963 | Pride
Human Melanoma Pdx Targeted therapy Rna pull-down Rap-ms 
ProteomicsGeneration of drug-tolerant cells by lncRNAs downstream of osmotic stress
Environmental cues within the tumor microenvironment (TME) affect tumor heterogeneity and plasticity, ultimately influencing therapy responses. Recent studies have shown that cancer stem cell niches are located near blood vessels and thus may be exposed to abrupt changes in the osmotic conditions. H...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD060369 | Pride
Incrnas Cancer Dda 
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