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TranscriptomicsMicroRNA expression profile of platelets in sickle cell disease
Circulating platelets from Sickle cell disease (SCD) patients express distinct gene expression patterns that regulate function. The objective of this study is to identify a role of post-transcriptional regulation of the platelet transcriptional signaling by microRNAs. Comparison of microRNA expressi...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41574 | biostudies-arrayexpress
TranscriptomicsSerotonergic regulation of melanocyte conversion: a bioelectric network explains stochastic all-or-none hyperpigmentation
Depolarization of resting membrane potential in select cells in Xenopus larvae induces striking hyperpigmentation due to dysregulation of melanocytes. Here, we show that this non-cell-autonomous process is mediated by cAMP, CREB, and the transcription factors Sox10 and Slug. Our microarray analysis ...
ORGANISM(S): Xenopus laevis 
2015-11-03 | E-GEOD-70834 | biostudies-arrayexpress
TranscriptomicsRole of platelet micrornas in sickle cell disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41575 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [frog data]
Endogenous bioelectric signaling via changes in cellular resting potential (Vmem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of Vmem has been functionally implicated in de-differentiation, tumorigenesis, anatomical re-specificatio...
ORGANISM(S): Xenopus laevis 
2016-07-03 | E-GEOD-72097 | biostudies-arrayexpress
Transcriptomicsgene expression in human subcutaneous adipose tissue after CLA intervention
Iisomer-specific effects of conjugated linoleic (CLA) supplementation on gene expression with particular consideration of the PPAR 2 Pro12Ala SNP in human adipose tissue. Effect of CLA supplementation on genome wide gene expression in adipose tissue biopsies from 5 PPARg2 Ala12Ala and 5 PPARg2 Pro12...
ORGANISM(S): Homo sapiens 
2009-09-01 | E-GEOD-16615 | biostudies-arrayexpress
TranscriptomicsGene expression data in Meg-01 cells following transfection with platelet-enriched microRNA-1225-3p
Platelets from sickle cell disease patients have differentially expressed microRNAs as compared to platelets from healthy control subjects. The objective of this study is to overexpress an upregulated miRNA,miR-1225-3p, in MEG01 cells to identify putative targets. MEG-01 cells were transfected with ...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41573 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of whole blood from sickle-cell disease patients using globin mRNA reduction
Room temperature whole blood mRNA stabilization procedures, such as the PAX gene system, are critical for the application of transcriptional analysis to population-based clinical studies. Global transcriptome analysis of whole blood RNA using microarrays has proven to be challenging due to the high ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16728 | biostudies-arrayexpress
TranscriptomicsDifferential expression analysis of HFF cells in G0 phase compared to cells in G1 [MAT]
Whole transcriptome differential expression analysis of HFF cells on Affymetrix Human Tiling 1.0 array set. Cells were synchronised by serum starvation and transcriptome-wide changes occurring at the transition from G0 phase to G1 phase detected. Expression data and fold changes were processed with ...
ORGANISM(S): Homo sapiens 
2012-12-18 | E-GEOD-36156 | biostudies-arrayexpress
TranscriptomicsPBMC IFNg Dose Reponse
PBMC response to three concentrations of IFNg (0.006, 0.6 and 60 pM) from 0-12h. Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and ind...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-16252 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiated 3T3-L1 pre-adipocytes.
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the conversion of saturated fatty acids palmitate and stearate to monounsaturated fatty acids palmitoleate and oleate. During adipocyte differentiation, SCD expression increases concomitantly with several transcription factors and ...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-51905 | biostudies-arrayexpress
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