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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [additional RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-73021 | biostudies-arrayexpress
TranscriptomicsTranscription of mammalian cis-regulatory elements is restrained by actively enforced early termination [RNA]
Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol_II) generates short non-coding transcripts of unclear function. The mechanisms that control the length and the amount of ncRNAs generated by cis-regulatory elements are largely unknown. Here, we show that the adapter protein ...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-66953 | biostudies-arrayexpress
UnknownA Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Not available
S-EPMC8518716 | biostudies-literature
UnknownWhich ante mortem clinical features predict progressive supranuclear palsy pathology?
Not available
S-EPMC5543934 | biostudies-literature
ProteomicsTargeted MRM assay Complement System in Health and Infectious Disease
The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...
ORGANISM(S): Homo Sapiens 
PXD014264 | panorama
UnknownQuality of life predicts outcome of deep brain stimulation in early Parkinson disease.
Not available
S-EPMC6442017 | biostudies-literature
UnknownCommon Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
Not available
S-EPMC10052809 | biostudies-literature
UnknownPerceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts.
Not available
S-EPMC11665388 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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