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TranscriptomicsTranscription profiling of human peripheral blood monocytes from a patient with a heterozygous deletion of the CARMA1 gene cultured with anti-CD3, anti-CD3 and anti-CD28 or lipopolysaccharide
PBMCs were isolated from whole blood taken from one patient and one healthy control. Cells were cultured in media (RPMI) alone, with 1µg/ml anti-CD3, with 1µg/ml anti-CD3 & 1µg/ml anti-CD28 or with 0.5ng/ml LPS. Cells were harvested after 24 or 48 hours, RNA isolated using Trizol, purified using R...
ORGANISM(S): Homo sapiens 
2022-04-01 | E-MTAB-101 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation [human data]
Endogenous bioelectric signaling via changes in cellular resting potential (Vmem) is a key regulator of patterning during regeneration and embryogenesis in numerous model systems. Depolarization of Vmem has been functionally implicated in de-differentiation, tumorigenesis, anatomical re-specificatio...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-72098 | biostudies-arrayexpress
UnknownRetrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City.
Not available
S-EPMC7702220 | biostudies-literature
GenomicsCHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61492 | biostudies-arrayexpress
TranscriptomicsHost gene expression profiling on children with any cause critical illness at retrieval or admission to paediatric critical care
We analysed data collected as part of the Biomarkers of Acute Serious Illness in Children (BASIC) study. BASIC was a prospective cohort study that enrolled critically ill children admitted to four PICUs in London and Eastern England, UK, during emergency transport by the Children’s Acute Transport S...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15164 | biostudies-arrayexpress
TranscriptomicsCHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [RNA-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61491 | biostudies-arrayexpress
GenomicsTranscriptional and Epigenetic Dynamics During Specification of Human Embryonic Stem Cells
Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the epigenetic mechanisms that facilitate cellular transitions in a human context. To that end, we performed comprehensive transcriptional and epigenetic profiling of early populations derived through direct...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-46130 | biostudies-arrayexpress
TranscriptomicsAnalysis of RIP-seq of Ded1 and eIF4A(Tif1) with and without glucose depletion
The aim of this experiment was to look at RNAs which associate with DEAD-box RNA helicases with and without 10 minutes of glucose starvation.
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9095 | biostudies-arrayexpress
ProteomicsLabel-Free Proteomics Profiling of Nanovesicles Isolated from Cultured Salivary Glands Isolated from Partially-Fed Adult Female Ixodes scapularis
Ticks are ectoparasites that have co-evolved with their hosts for millions of years. Unlike other blood-feeders, hard ticks take several days to complete a blood-meal, which makes them especially susceptible to the detection by host immune responses. To overcome this, ticks have developed a vast arr...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) 
2021-06-07 | PXD018779 | Pride
Salivary glands ixodes scapularis  label free proteomics  qexactive nano-lc/ms/ms 
TranscriptomicsAnalysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. Here we perform RIP-seq to determine the RNA interactors of Dcp1 (PB marker) and Pbp1 (SG marker) before and afte...
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9096 | biostudies-arrayexpress
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