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ProteomicsMammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell types, is essential for cell proliferation. Why OGT is required for cell growth is not known. OGT performs two enzymatic reactions in the same active site. In one, it glycosylates thousands of different proteins, an...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022654 | Pride
O-glcnac transferase Ogt Enzyme Cell proliferation Hcf-1 
ProteomicsAspartate residues far from the active site drive O-GlcNAc transferase substrate selection
Here we use protein microarray technology and proteome-wide glycosylation profiling to show that conserved aspartate residues in the tetratricopeptide repeat (TPR) lumen of OGT drive substrate selection. Changing these residues to alanines alters substrate selectivity and unexpectedly increases rate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-26 | PXD014731 | Pride
Glycoproteomics O-glcnac 
UnknownAspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.
Not available
S-EPMC6849375 | biostudies-literature
UnknownOverexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines.
Not available
S-EPMC6726474 | biostudies-literature
UnknownO-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity.
Not available
S-EPMC8102337 | biostudies-literature
UnknownO-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.
Not available
S-EPMC5607117 | biostudies-literature
UnknownTranslation and validation of the Arabic version of the Morisky, Green and Levine (MGL) adherence scale.
Not available
S-EPMC9543961 | biostudies-literature
UnknownO-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
Not available
S-EPMC6860926 | biostudies-literature
UnknownDisruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.
Not available
S-EPMC4839001 | biostudies-literature
UnknownIn silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages.
Not available
S-EPMC5343136 | biostudies-literature
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