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ProteomicsCrosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.
To evaluate the downstream effects of anti-Ly6a crosslinking, we examined the effect of anti-Ly6a antibodies on CD8+ T cell activity in the presence and absence of target tumor cells by high-resolution mass spectrometry proteomic analyses. Spleen cells were isolated from gp10025–33 TCR transgenic mi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-04 | PXD050734 | Pride
Uvb Cd8 t cells Cancer immunotherapy T cells metabolism 
ProteomicsSkin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025973 | Pride
Proteomics Uvb light Sexual behavior 
ProteomicsSolar exposed skin induces sex-dependent food-seeking behavior
Considering the distinct physiologies of men and women, it stands to reason that they would react differently to solar exposure, but such a study was never conducted before. Here we show that solar exposure induces food-seeking behavior, food intake and weight gain in males, but not in females, by ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033203 | Pride
Food-seeking Solar exposure Serum 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 2
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035648 | Pride
Metabolism Cancer Exercise 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 1
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035630 | Pride
Metabolism Cancer Exercise 
ProteomicsMalaria Parasites Hijack Immune Host Splicing Machinery Using Decoy RNAs
Malaria, the most serious mosquito-borne parasitic disease, is mainly caused by the lethal parasite Plasmodium falciparum (Pf), which grows within human red blood cells (RBCs). This master of survival is known for utilizing sophisticated defense strategies to alter the host's immune response. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD054139 | Pride
Plasmodium falciparum Virulence Decoy rnas 
UnknownEvolthon: A community endeavor to evolve lab evolution.
Not available
S-EPMC6440615 | biostudies-literature
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