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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownIncorporating Digital Tools to Improve Clinical Trial Infrastructure: A White Paper From the Digital Engagement Committee of SWOG.
Not available
S-EPMC6668704 | biostudies-literature
ModelsNorsigian2018 - A. baumannii (iCN718)
FROG and miniFROG Reports for the organism A. baumannii. The model (iCN718) originates from BiGG Models Database: A Database of Genome-Scale Metabolic Models (http://bigg.ucsd.edu/). Copyright © 2019 The Regents of the University of California To cite BiGG Models Database, ple...
2024-10-15 | BIOMD0000001085 | BioModels
FROG 
UnknownHCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy-treated HIV/HCV-co-infected subjects.
Not available
S-EPMC5589504 | biostudies-literature
TranscriptomicsGPBAR1 agonism has a broad impact on blocking macrophage activation
Human D14+ / CD16+ monocytes were treated with GPBAR1 agonists or controls, and were stimulated with interferon gamma and LPS. At 6 and 24 hours, the cells were profiled by RNAseq 40 total samples, 5 per group with eight groups. Individual donors used for multiple comparisons, so paired analysis ...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-57494 | biostudies-arrayexpress
ProteomicsCRISPR-Cas9 Editing of TLR4 Improves the Outcome of Cardiac Cell Therapy
We developed and optimized a new electroporation protocol for CRISPR-Cas9 gene editing. This protocol achieved up to 68% success rate, when applied to isolated hMSCs from the heart and epicardial fat of patients with ischemic heart disease. While cell editing resulted lowered TLR4 expression in hMSC...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033253 | Pride
Tlr4 Cell therapy Mesenchymal stromal cells 
UnknownCombined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor.
Not available
S-EPMC4226803 | biostudies-literature
TranscriptomicsGene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW and WKY
WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and ...
ORGANISM(S): Rattus norvegicus 
2014-08-31 | E-MTAB-2719 | biostudies-arrayexpress
Genomics273ad39f-3094-4126-a10e-96c1321a07fb - samples
FastQ files with paired-end RNAseq data for human fetal brain homogenate from 120 samples (12-19 post-conception weeks).
EGAD00001004363 | EGA
GenomicsFBSeq: RNA sequencing of human fetal brain.
RNA sequencing of 120 human fetal brains (aged 12-19 post-conception weeks) was performed as part of a Medical Research Council (U.K.) funded project (MR/L010674/2) to investigate genetic effects on gene expression in the developing human brain and their role in neuropsychiatric disorders. Human fet...
EGAS00001003214 | EGA
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