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Mass spectrometry profiling of orthotopically transplanted breast cancer patient-derived xenograft (PDX) tumors prior to chemotherapy treatment.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-12-06 | PXD035857 | Pride
The authors develop a novel computational algorithm that identified two signatures of differential response to platinum-based and taxane chemotherapies in breast cancer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088233 | MassIVE

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
Hedgehog (Hh) signaling is critical for organogenesis, tissue homeostasis, and stem cell maintenance. Smoothened (SMO), the primary effector of Hh signaling, is expressed ectopically in human breast cancer, as well as in other cancers. Constitutive activation of SMO in mouse mammary glands leads t...
ORGANISM(S): Mus musculus 
Chromosomal instability is central to the process of carcinogenesis. The detection of somatic chromosomal alterations in small premalignant lesions genome-wide remains challenging since sample heterogeneity dilutes the aberrant cell information. We introduced an analytic metric termed "delta-θ&...
ORGANISM(S): Homo sapiens 
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