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MetabolomicsPlasma sphingolipid changes with autopsy-confirmed Lewy body or Alzheimer's pathology
Not available
ORGANISM(S): Homo sapiens 
ST000433 | MetabolomicsWorkbench
GenomicsLewy Body Disease Gut Microbiome Shotgun Metagenomics Sequencing
Lewy Body Disease Gut Microbiome
PRJNA1393457 | ENA
UnknownListening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel.
Not available
S-EPMC9983146 | biostudies-literature
GenomicsBulk-tissue RNA-sequencing of anterior cingulate cortex samples derived from Lewy body disease patients
Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have...
EGAS00001005305 | EGA
ProteomicsAltered ceramide metabolism is a feature in the extracellular vesicle mediated spread of alpha-synuclein in sporadic and GBA-linked Lewy body disease
Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD) – collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutation contributes to the susc...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026980 | Pride
Exosomes Alpha-synuclein Ceramide Inflammation Lewy body disease Extracellular vesicles Glucocerebrosidase 
MetabolomicsMetabolomics of sebum reveals lipid dysregulation in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...
2020-12-21 | MTBLS2266 | MetaboLights
GenomicsBrain transcriptomic analysis in Parkinson's disease patients stratified by Braak Lewy body stage / Sex differences in Parkinson's disease brain transcriptome
Brain transcriptomic analysis in Parkinson's disease patients stratified by Braak Lewy body stage / Sex differences in Parkinson's disease brain transcriptome
PRJNA892925 | ENA
UnknownFamily Caregiver Comorbidities in Lewy Body Dementia Versus Alzheimer Disease and Associated Disorders.
Not available
S-EPMC10204123 | biostudies-literature
UnknownResearch priorities of caregivers and individuals with dementia with Lewy bodies: An interview study.
Not available
S-EPMC7540843 | biostudies-literature
ProteomicsProteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss
Proteinaceous aggregates containing alpha-synuclein protein called Lewy bodies in the substantia nigra is a hallmark of Parkinson's disease. The molecular mechanisms of Lewy body formation and associated neuronal loss remain largely unknown. To gain insights on proteins and pathways associated with ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD019279 | Pride
Brain Lewy bodies Substantia nigra Lc-ms/ms 
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