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ProteomicsLarge-scale filter-aided sample preparation method for the analysis of the ubiquitinome
Protein ubiquitination regulates key cellular functions including protein homeostasis and signal transduction. The digestion of ubiquitinated proteins with trypsin yields a glycine-glycine remnant bound to the modified lysine residue (K-ε-GG) that can be recognized by specific antibodies for immunoa...
ORGANISM(S): Homo sapiens (Human) 
2017-03-30 | PXD005421 | Pride
Ubiquitinome Large-scale Portein digestion Post-translational modifications Lfasp Proteome 
ProteomicsA phosphoproteomic analysis of platelets in severe obesity uncovers platelet reactivity and signaling pathways alterations
Objective: Obesity is associated with a pro-inflammatory and pro-thrombotic state that supports atherosclerosis progression. The goal of this study was to gain insights into the phosphorylation events related to platelet reactivity in obesity and identify platelet biomarkers and altered activation p...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD020204 | Pride
Obesity Biomarkers Platelets Quantitative phosphoproteomics 
ProteomicsTCellXTalk enables the detection of co-modified peptides for the study of protein post-translational modification cross-talk in T cells
Protein function is regulated by post-translational modifications (PTMs) that may act individually or interact with others in a phenomenon termed PTM cross-talk. Multiple databases have been dedicated to PTMs, including recent initiatives oriented to the in silico prediction of PTM interactions. The...
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD010176 | Pride
Ptms Cross-talk Tcr activation T cells 
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