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ProteomicsUbiquitinome profiling reveals in vivo UBE2D3 targets and implicates UBE2D3 in protein quality control.
Ubiquitination has crucial roles in many cellular processes and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets. As individual E2 enzym...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-13 | PXD035045 | Pride
Ubiquitinome Silac Ube2d3 
ProteomicsLarge-scale filter-aided sample preparation method for the analysis of the ubiquitinome
Protein ubiquitination regulates key cellular functions including protein homeostasis and signal transduction. The digestion of ubiquitinated proteins with trypsin yields a glycine-glycine remnant bound to the modified lysine residue (K-ε-GG) that can be recognized by specific antibodies for immunoa...
ORGANISM(S): Homo sapiens (Human) 
2017-03-30 | PXD005421 | Pride
Ubiquitinome Large-scale Portein digestion Post-translational modifications Lfasp Proteome 
ProteomicsUbiquitinome of G401 SMARCB1-deficient rhabdoid tumor cells
In this study, DCAF5, a substrate receptor that has been shown to modulate the levels of SWI/SNF subunits, which are components of a chromatin remodeling complex. Here we preformed ubiquitinome proteomics to discover the underlying response of DCAF5 loss on ubiquitylation of SWI/SNF subunits. Furthe...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD046463 | Pride
Ubiquitinome Tmtpro Swi/snf Dcaf5 
ProteomicsRoot membrane ubiquitinome under osmotic stress reveals specific post-translational modification patterns
Osmotic stress is detrimental for the plant which survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification (PTM) in osmotic mediated stress. Plants use the ubiquitin proteasome system to modulate protein contents required to respond to and ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-04 | PXD022249 | Pride
Post-translational modification Mass spectrometry Osmotic stress Ubiquitination Aquaporin 
ProteomicsUbiquitinome UPS - Quantitative proteomics reveals extensive changes in the ubiquitinome after perturbation of the proteasome by targeted dsRNA mediated subunit knockdown in Drosophila
In eukaryotic cells, short-lived, regulatory and misfolded or denatured proteins are degraded by the ubiquitin–proteasome system (UPS), a highly regulated mechanism including the active marking of proteins for proteasomal degradation by ubiquitin. The UPS is critical in regulating proteostasis and d...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-07-03 | PXD002552 | Pride
Ubiquitinome Digly Silac Proteasome Lc-ms/ms 
UnknownThe functional landscape of the human ubiquitinome.
Not available
S-EPMC12632403 | biostudies-literature
ProteomicsUbiquitinome of Plasmodium yoelii lines NSS and NSR
Ubiquitinome profiling of blood stages of Plasmodium yoelii lines NSS and NSR
ORGANISM(S): Plasmodium yoelii 
2024-02-04 | PXD047782 | Pride
Ubiquitinome Lc-msms Plasmodium yoelii 
UnknownRoot Membrane Ubiquitinome under Short-Term Osmotic Stress.
Not available
S-EPMC8879470 | biostudies-literature
UnknownUbiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles.
Not available
S-EPMC7801245 | biostudies-literature
ProteomicsThe global Proteome and Ubiquitinome of bacterial and viral co-infected Bronchial Epithelial Cells
Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial viral co infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses. Epithelial cells ...
ORGANISM(S): Homo Sapiens Staphylococcus Aureus Influenza A Virus (a/germany-by/74/2009(h1n1)) Streptococcus Pyogenes 
2022-06-13 | PXD026625 | panorama
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