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ProteomicsUbiquitinome profiling reveals in vivo UBE2D3 targets and implicates UBE2D3 in protein quality control and H2B monoubiquitination
Ubiquitination has crucial roles in many cellular processes and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of E2 ubiquitin-conjugating enzymes to support the ubiquitination of many cellular targets. As individual E2 enzymes...
ORGANISM(S): Homo sapiens (Human) 
2023-04-12 | PXD026054 | Pride
Ube2d3 Ubiquitin 
ProteomicsUbiquitinome profiling reveals in vivo UBE2D3 targets and implicates UBE2D3 in protein quality control.
Ubiquitination has crucial roles in many cellular processes and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets. As individual E2 enzym...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-13 | PXD035045 | Pride
Ubiquitinome Silac Ube2d3 
UnknownUbiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.
Not available
S-EPMC10209342 | biostudies-literature
ProteomicsUBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Maintenance of genome integrity requires tight control of DNA damage signalling and repair activities at DNA lesions, as well as their restriction at telomeres. Key components of the mechanisms underlying appropriate responses to DNA damage include phosphorylation events by DNA damage response (DDR)...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD044410 | Pride
Molecular biology Non-homologous-end joining Rnf168 Dna damage and repair Ube2d3 Lc-msms Telomere 
GenomicsTranscriptome analysis for modulating ubiquitin siganlling in the amniote embryo via phosphoregulation of the E2 enzyme UBE2D3
Transcriptome analysis for modulating ubiquitin siganlling in the amniote embryo via phosphoregulation of the E2 enzyme UBE2D3
PRJNA485078 | ENA
GenomicsUBE2D3 is an Intracellular Checkpoint in Pancreatic Ductal Carcinoma that Restricts CD8+ T-Cell Antitumor Immunity
UBE2D3 is an Intracellular Checkpoint in Pancreatic Ductal Carcinoma that Restricts CD8+ T-Cell Antitumor Immunity
PRJNA1124987 | ENA
UnknownEupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3.
Not available
S-EPMC11731104 | biostudies-literature
UnknownComprehensive bioinformatics analysis reveals the role of cuproptosis-related gene Ube2d3 in myocardial infarction.
Not available
S-EPMC10909922 | biostudies-literature
TranscriptomicsTranscriptome analysis for modulating ubiquitin siganlling in the amniote embryo via phosphoregulation of the E2 enzyme UBE2D3
Purpose: Understanding the transcriptional effects of a gain of function mutation of the E2 enzyme UBE2D3 in embryonic stem cells Methods: mRNA profiles of wt E14 ES cells and UBE2D3 Ser138Ala mutant ES cells were generated
ORGANISM(S): Mus musculus 
2021-08-03 | GSE118287 | GEO
TranscriptomicsUBE2D3 is an Intracellular Checkpoint in Pancreatic Ductal Carcinoma that Restricts CD8+ T-Cell Antitumor Immunity
Ubiquitylation is pivotal in regulating cellular responses, with its aberration implicated in tumor immune evasion. However, the impact of ubiquitin-conjugating enzymes (E2s) on this evasion remains unclear. Here, we employ a systematic approach to demonstrate that in pancreatic ductal carcinoma (PD...
ORGANISM(S): Mus musculus 
2024-06-21 | GSE270097 | GEO
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